Exposure to Perfluoro-Octanoic Acid Associated With Upstream Uncoupling of the Insulin Signaling in Human Hepatocyte Cell Line

Exposure to Perfluoro-Octanoic Acid Associated With Upstream Uncoupling of the Insulin Signaling in Human Hepatocyte Cell Line

Perfluoro–alkyl substances (PFAS) are chemical pollutants with prevalent stability and environmental persistence. Exposure to PFAS, particularly perfluoro-octanoic acid (PFOA), has been associated with increased diabetes-related cardiovascular mortality in subjects residing areas of high environment...

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Bibliographic Details
Main Authors: Luca De Toni, Andrea Di Nisio, Maria Santa Rocca, Diego Guidolin, Alice Della Marina, Loris Bertazza, Stefania Sut, Edoardo Purpura, Micaela Pannella, Andrea Garolla, Carlo Foresta
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Endocrinology
Subjects:
glycogen
membrane
glut-4
GM3
PDMP
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.632927/full

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