An organocatalytic route to 2-heteroarylmethylene decorated N-arylpyrroles

An organocatalytic route to 2-heteroarylmethylene decorated N-arylpyrroles

A concise and regioselective preparation of 2-heteroarylmethylene decorated N-arylpyrroles is described through a metal-free Mannich/Wittig/hydroamination sequence followed by isomerization of the N-arylpyrrolidine adducts. Furthermore, the C–H regioselective oxidation of these substrates is demonst...

Full description

Bibliographic Details
Main Authors: Alexandre Jean, Jérôme Blanchet, Jacques Rouden, Jacques Maddaluno, Michaël De Paolis
Format: Article
Language:English
Published: Beilstein-Institut 2013-07-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
C–H oxidation
isomerization
N-arylpyrrole
organocatalysis
Online Access:https://doi.org/10.3762/bjoc.9.168
Description
Summary:A concise and regioselective preparation of 2-heteroarylmethylene decorated N-arylpyrroles is described through a metal-free Mannich/Wittig/hydroamination sequence followed by isomerization of the N-arylpyrrolidine adducts. Furthermore, the C–H regioselective oxidation of these substrates is demonstrated, extending the molecular diversity and versatility of these scaffolds.
ISSN:1860-5397

Similar Items