Recent advances in understanding Kaposi’s sarcoma-associated herpesvirus [version 1; referees: 2 approved]

Recent advances in understanding Kaposi’s sarcoma-associated herpesvirus [version 1; referees: 2 approved]

Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is an oncogenic human herpesvirus. KSHV is associated with three cancers in the human population: KS, primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD). KS is the leading cause of cancer in HIV-infected individuals. In thi...

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Bibliographic Details
Main Authors: Nathan J. Dissinger, Blossom Damania
Format: Article
Language:English
Published: F1000 Research Ltd 2016-04-01
Series:F1000Research
Subjects:
Antimicrobials & Drug Resistance
Cell Signaling
Cellular Death & Stress Responses
Cellular Microbiology & Pathogenesis
Control of Gene Expression
Medical Microbiology
Nuclear Structure & Function
Virology
Online Access:http://f1000research.com/articles/5-740/v1
Description
Summary:Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is an oncogenic human herpesvirus. KSHV is associated with three cancers in the human population: KS, primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD). KS is the leading cause of cancer in HIV-infected individuals. In this review, we discuss the most recent discoveries behind the mechanisms of KSHV latency maintenance and lytic replication. We also review current therapies for KSHV-associated cancers.
ISSN:2046-1402

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