Platelets miRNA as a Prediction Marker of Thrombotic Episodes

Platelets miRNA as a Prediction Marker of Thrombotic Episodes

The blood platelets are crucial for the coagulation physiology to maintain haemostatic balance and are involved in various pathologies such as atherosclerosis and thrombosis. The studies of recent years have shown that anucleated platelets are able to succeed protein synthesis. Additionally, mRNA tr...

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Main Authors: Michal Bijak, Malgorzata Dzieciol, Joanna Rywaniak, Joanna Saluk, Marzenna Zielinska
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2016/2872507
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spelling doaj-a55ffde6a57e48e8b3d49351533a66ce2020-11-24T21:52:52ZengHindawi LimitedDisease Markers0278-02401875-86302016-01-01201610.1155/2016/28725072872507Platelets miRNA as a Prediction Marker of Thrombotic EpisodesMichal Bijak0Malgorzata Dzieciol1Joanna Rywaniak2Joanna Saluk3Marzenna Zielinska4Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, PolandIntensive Cardiac Therapy Clinic, Medical University of Lodz, Pomorska 251, 91-213 Lodz, PolandDepartment of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, PolandDepartment of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, PolandIntensive Cardiac Therapy Clinic, Medical University of Lodz, Pomorska 251, 91-213 Lodz, PolandThe blood platelets are crucial for the coagulation physiology to maintain haemostatic balance and are involved in various pathologies such as atherosclerosis and thrombosis. The studies of recent years have shown that anucleated platelets are able to succeed protein synthesis. Additionally, mRNA translation in blood platelets is regulated by miRNA molecules. Recent works postulate the possibility of using miRNAs as biomarkers of atherosclerosis and ischemic episodes. This review article describes clinical studies that presented blood platelets miRNAs expression profile changes in different thrombotic states, which suggest use of these molecules as predictive biomarkers.http://dx.doi.org/10.1155/2016/2872507
collection DOAJ
language English
format Article
sources DOAJ
author Michal Bijak
Malgorzata Dzieciol
Joanna Rywaniak
Joanna Saluk
Marzenna Zielinska
spellingShingle Michal Bijak
Malgorzata Dzieciol
Joanna Rywaniak
Joanna Saluk
Marzenna Zielinska
Platelets miRNA as a Prediction Marker of Thrombotic Episodes
Disease Markers
author_facet Michal Bijak
Malgorzata Dzieciol
Joanna Rywaniak
Joanna Saluk
Marzenna Zielinska
author_sort Michal Bijak
title Platelets miRNA as a Prediction Marker of Thrombotic Episodes
title_short Platelets miRNA as a Prediction Marker of Thrombotic Episodes
title_full Platelets miRNA as a Prediction Marker of Thrombotic Episodes
title_fullStr Platelets miRNA as a Prediction Marker of Thrombotic Episodes
title_full_unstemmed Platelets miRNA as a Prediction Marker of Thrombotic Episodes
title_sort platelets mirna as a prediction marker of thrombotic episodes
publisher Hindawi Limited
series Disease Markers
issn 0278-0240
1875-8630
publishDate 2016-01-01
description The blood platelets are crucial for the coagulation physiology to maintain haemostatic balance and are involved in various pathologies such as atherosclerosis and thrombosis. The studies of recent years have shown that anucleated platelets are able to succeed protein synthesis. Additionally, mRNA translation in blood platelets is regulated by miRNA molecules. Recent works postulate the possibility of using miRNAs as biomarkers of atherosclerosis and ischemic episodes. This review article describes clinical studies that presented blood platelets miRNAs expression profile changes in different thrombotic states, which suggest use of these molecules as predictive biomarkers.
url http://dx.doi.org/10.1155/2016/2872507
work_keys_str_mv AT michalbijak plateletsmirnaasapredictionmarkerofthromboticepisodes
AT malgorzatadzieciol plateletsmirnaasapredictionmarkerofthromboticepisodes
AT joannarywaniak plateletsmirnaasapredictionmarkerofthromboticepisodes
AT joannasaluk plateletsmirnaasapredictionmarkerofthromboticepisodes
AT marzennazielinska plateletsmirnaasapredictionmarkerofthromboticepisodes
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