Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity[S]

Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity[S]

Studies in skeletal muscle demonstrate that elevation of plasma FFAs increases the sphingolipid ceramide. We aimed to determine the impact of FFA oversupply on total sphingolipid profiles in a skeletal muscle model. C2C12 myotubes were treated with palmitate (PAL). Lipidomics analysis revealed pleio...

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Bibliographic Details
Main Authors:	Wei Hu, Jacek Bielawski, Fahumiya Samad, Alfred H. Merrill, Jr., L. Ashley Cowart
Format:	Article
Language:	English
Published:	Elsevier 2009-09-01
Series:	Journal of Lipid Research
Subjects:	free fatty acid sphingolipid ceramide skeletal muscle insulin resistance diabetes
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520307379

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