Functional Analysis of Familial Asp67Glu and Thr1051Ser BRCA1 Mutations in Breast/Ovarian Carcinogenesis

Functional Analysis of Familial Asp67Glu and Thr1051Ser BRCA1 Mutations in Breast/Ovarian Carcinogenesis

Estrogen is believed to be pre-initiator in the risk of breast cancer. The BRCA1 is a tumor suppressor gene associated with breast and ovarian cancer risk. This report describes functional analysis of two BRCA1 missense mutations (Asp67Glu and Thr1051Ser) observed in the familial breast/ovarian canc...

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Bibliographic Details
Main Authors: Grady F. Saunders, Pimpicha Patmasiriwat, Malinee Pongsavee
Format: Article
Language:English
Published: MDPI AG 2009-09-01
Series:International Journal of Molecular Sciences
Subjects:
BRCA1 missense mutation
estrogen
estrogen receptor signaling pathway
breast/ovarian carcinogenesis
Online Access:http://www.mdpi.com/1422-0067/10/9/4187/

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