Cwp19 Is a Novel Lytic Transglycosylase Involved in Stationary-Phase Autolysis Resulting in Toxin Release in Clostridium difficile

Cwp19 Is a Novel Lytic Transglycosylase Involved in Stationary-Phase Autolysis Resulting in Toxin Release in Clostridium difficile

Clostridium difficile is the major etiologic agent of antibiotic-associated intestinal disease. Pathogenesis of C. difficile is mainly attributed to the production and secretion of toxins A and B. Unlike most clostridial toxins, toxins A and B have no signal peptide, and they are therefore secreted...

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Bibliographic Details
Main Authors: Sandra Wydau-Dematteis, Imane El Meouche, Pascal Courtin, Audrey Hamiot, René Lai-Kuen, Bruno Saubaméa, François Fenaille, Marie-José Butel, Jean-Louis Pons, Bruno Dupuy, Marie-Pierre Chapot-Chartier, Johann Peltier
Format: Article
Language:English
Published: American Society for Microbiology 2018-06-01
Series:mBio
Subjects:
Clostridium difficile
autolysins
lytic transglycosylase
peptidoglycan
surface proteins
toxins
Online Access:https://doi.org/10.1128/mBio.00648-18

Internet

https://doi.org/10.1128/mBio.00648-18

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