Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

Radiation-induced meningiomas are often more aggressive than sporadic ones. In this study, the authors perform an exome, methylation and RNA-seq analysis of 31 cases of radiation-induced meningioma and show NF2 rearrangement, an observation previously unreported in the sporadic tumors.

Bibliographic Details
Main Authors:	Sameer Agnihotri, Suganth Suppiah, Peter D. Tonge, Shahrzad Jalali, Arnavaz Danesh, Jeffery P. Bruce, Yasin Mamatjan, George Klironomos, Lior Gonen, Karolyn Au, Sheila Mansouri, Sharin Karimi, Felix Sahm, Andreas von Deimling, Michael D. Taylor, Normand J. Laperriere, Trevor J. Pugh, Kenneth D. Aldape, Gelareh Zadeh
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00174-7

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spelling	doaj-a54fecc0556f4be88b38c63cf07148b52021-01-31T12:33:56ZengNature Publishing GroupNature Communications2041-17232017-08-01811710.1038/s41467-017-00174-7Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomasSameer Agnihotri0Suganth Suppiah1Peter D. Tonge2Shahrzad Jalali3Arnavaz Danesh4Jeffery P. Bruce5Yasin Mamatjan6George Klironomos7Lior Gonen8Karolyn Au9Sheila Mansouri10Sharin Karimi11Felix Sahm12Andreas von Deimling13Michael D. Taylor14Normand J. Laperriere15Trevor J. Pugh16Kenneth D. Aldape17Gelareh Zadeh18MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health NetworkMacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health NetworkMacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health NetworkMacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer CentrePrincess Margaret Cancer CentreMacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health NetworkMacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health NetworkMacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health NetworkMacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health NetworkMacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health NetworkMacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health NetworkDepartment of Neuropathology, Institute of PathologyUniversity Hospital HeidelbergDepartment of Neuropathology, Institute of PathologyUniversity Hospital HeidelbergDepartment of Surgery, Division of Neurosurgery, University of TorontoMacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer CentreMacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health NetworkMacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health NetworkRadiation-induced meningiomas are often more aggressive than sporadic ones. In this study, the authors perform an exome, methylation and RNA-seq analysis of 31 cases of radiation-induced meningioma and show NF2 rearrangement, an observation previously unreported in the sporadic tumors.https://doi.org/10.1038/s41467-017-00174-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sameer Agnihotri Suganth Suppiah Peter D. Tonge Shahrzad Jalali Arnavaz Danesh Jeffery P. Bruce Yasin Mamatjan George Klironomos Lior Gonen Karolyn Au Sheila Mansouri Sharin Karimi Felix Sahm Andreas von Deimling Michael D. Taylor Normand J. Laperriere Trevor J. Pugh Kenneth D. Aldape Gelareh Zadeh
spellingShingle	Sameer Agnihotri Suganth Suppiah Peter D. Tonge Shahrzad Jalali Arnavaz Danesh Jeffery P. Bruce Yasin Mamatjan George Klironomos Lior Gonen Karolyn Au Sheila Mansouri Sharin Karimi Felix Sahm Andreas von Deimling Michael D. Taylor Normand J. Laperriere Trevor J. Pugh Kenneth D. Aldape Gelareh Zadeh Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas Nature Communications
author_facet	Sameer Agnihotri Suganth Suppiah Peter D. Tonge Shahrzad Jalali Arnavaz Danesh Jeffery P. Bruce Yasin Mamatjan George Klironomos Lior Gonen Karolyn Au Sheila Mansouri Sharin Karimi Felix Sahm Andreas von Deimling Michael D. Taylor Normand J. Laperriere Trevor J. Pugh Kenneth D. Aldape Gelareh Zadeh
author_sort	Sameer Agnihotri
title	Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas
title_short	Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas
title_full	Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas
title_fullStr	Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas
title_full_unstemmed	Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas
title_sort	therapeutic radiation for childhood cancer drives structural aberrations of nf2 in meningiomas
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-08-01
description	Radiation-induced meningiomas are often more aggressive than sporadic ones. In this study, the authors perform an exome, methylation and RNA-seq analysis of 31 cases of radiation-induced meningioma and show NF2 rearrangement, an observation previously unreported in the sporadic tumors.
url	https://doi.org/10.1038/s41467-017-00174-7
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Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

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