Structure and Biophysical Properties of a Triple-Stranded Beta-Helix Comprising the Central Spike of Bacteriophage T4

Structure and Biophysical Properties of a Triple-Stranded Beta-Helix Comprising the Central Spike of Bacteriophage T4

Gene product 5 (gp5) of bacteriophage T4 is a spike-shaped protein that functions to disrupt the membrane of the target cell during phage infection. Its C-terminal domain is a long and slender β-helix that is formed by three polypeptide chains wrapped around a common symmetry axis akin to three inte...

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Bibliographic Details
Main Authors: Sergey A. Buth, Laure Menin, Mikhail M. Shneider, Jürgen Engel, Sergei P. Boudko, Petr G. Leiman
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Viruses
Subjects:
β-helical proteins
fibrous proteins
protein folding
X-ray crystallography
fatty acid
mass spectrometry
intrinsic protein fluorescence
protein stability
amyloid-like structure
low complexity amino acid sequence
Online Access:http://www.mdpi.com/1999-4915/7/8/2839

Internet

http://www.mdpi.com/1999-4915/7/8/2839

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