Oral rapamycin attenuates atherosclerosis without affecting the arterial responsiveness of resistance vessels in apolipoprotein E-deficient mice

Oral rapamycin attenuates atherosclerosis without affecting the arterial responsiveness of resistance vessels in apolipoprotein E-deficient mice

The objective of the present study was to assess the effects of the immunosuppressant rapamycin (Rapamune®, Sirolimus) on both resistance vessel responsiveness and atherosclerosis in apolipoprotein E-deficient 8-week-old male mice fed a normal rodent diet. Norepinephrine (NE)-induced vasoconstrictio...

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Bibliographic Details
Main Authors: A.L.N. Gadioli, B.V. Nogueira, R.M.P. Arruda, R.B. Pereira, S.S. Meyrelles, J.A. Arruda, E.C. Vasquez
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2009-12-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Rapamycin
Sirolimus
Atherosclerosis
Vascular responsiveness
Apolipoprotein E
Mice
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200012

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200012

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