Utility of Computational Methods to Identify the Apoptosis Machinery in Unicellular Eukaryotes

Apoptosis is the phenotypic result of an active, regulated process of self-destruction. Following various cellular insults, apoptosis has been demonstrated in numerous unicellular eukaryotes, but very little is known about the genes and proteins that initiate and execute this process in this group o...

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Main Authors:	Pierre Marcel Durand, Theresa Louise Coetzer
Format:	Article
Language:	English
Published:	SAGE Publishing 2008-01-01
Series:	Bioinformatics and Biology Insights
Subjects:	bioinformatics programmed cell death apoptosis protozoa
Online Access:	http://la-press.com/article.php?article_id=605

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spelling	doaj-a542a2bcc6c3487f913fc1582dc6f96b2020-11-25T03:13:23ZengSAGE PublishingBioinformatics and Biology Insights1177-93222008-01-012101117Utility of Computational Methods to Identify the Apoptosis Machinery in Unicellular EukaryotesPierre Marcel DurandTheresa Louise CoetzerApoptosis is the phenotypic result of an active, regulated process of self-destruction. Following various cellular insults, apoptosis has been demonstrated in numerous unicellular eukaryotes, but very little is known about the genes and proteins that initiate and execute this process in this group of organisms. A bioinformatic approach presents an array of powerful methods to direct investigators in the identification of the apoptosis machinery in protozoans. In this review, we discuss some of the available computational methods and illustrate how they may be applied using the identification of a Plasmodium falciparum metacaspase gene as an example.http://la-press.com/article.php?article_id=605bioinformaticsprogrammed cell deathapoptosisprotozoa
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Pierre Marcel Durand Theresa Louise Coetzer
spellingShingle	Pierre Marcel Durand Theresa Louise Coetzer Utility of Computational Methods to Identify the Apoptosis Machinery in Unicellular Eukaryotes Bioinformatics and Biology Insights bioinformatics programmed cell death apoptosis protozoa
author_facet	Pierre Marcel Durand Theresa Louise Coetzer
author_sort	Pierre Marcel Durand
title	Utility of Computational Methods to Identify the Apoptosis Machinery in Unicellular Eukaryotes
title_short	Utility of Computational Methods to Identify the Apoptosis Machinery in Unicellular Eukaryotes
title_full	Utility of Computational Methods to Identify the Apoptosis Machinery in Unicellular Eukaryotes
title_fullStr	Utility of Computational Methods to Identify the Apoptosis Machinery in Unicellular Eukaryotes
title_full_unstemmed	Utility of Computational Methods to Identify the Apoptosis Machinery in Unicellular Eukaryotes
title_sort	utility of computational methods to identify the apoptosis machinery in unicellular eukaryotes
publisher	SAGE Publishing
series	Bioinformatics and Biology Insights
issn	1177-9322
publishDate	2008-01-01
description	Apoptosis is the phenotypic result of an active, regulated process of self-destruction. Following various cellular insults, apoptosis has been demonstrated in numerous unicellular eukaryotes, but very little is known about the genes and proteins that initiate and execute this process in this group of organisms. A bioinformatic approach presents an array of powerful methods to direct investigators in the identification of the apoptosis machinery in protozoans. In this review, we discuss some of the available computational methods and illustrate how they may be applied using the identification of a Plasmodium falciparum metacaspase gene as an example.
topic	bioinformatics programmed cell death apoptosis protozoa
url	http://la-press.com/article.php?article_id=605
work_keys_str_mv	AT pierremarceldurand utilityofcomputationalmethodstoidentifytheapoptosismachineryinunicellulareukaryotes AT theresalouisecoetzer utilityofcomputationalmethodstoidentifytheapoptosismachineryinunicellulareukaryotes
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Utility of Computational Methods to Identify the Apoptosis Machinery in Unicellular Eukaryotes

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