NRF2 Mutation Confers Malignant Potential and Resistance to Chemoradiation Therapy in Advanced Esophageal Squamous Cancer

NRF2 Mutation Confers Malignant Potential and Resistance to Chemoradiation Therapy in Advanced Esophageal Squamous Cancer

Esophageal squamous cancer (ESC) is one of the most aggressive tumors of the gastrointestinal tract. A combination of chemotherapy and radiation therapy (CRT) has improved the clinical outcome, but the molecular background determining the effectiveness of therapy remains unknown. NRF2 is a master t...

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Bibliographic Details
Main Authors: Tatsuhiro Shibata, Akiko Kokubu, Shigeru Saito, Mako Narisawa-Saito, Hiroki Sasaki, Kazuhiko Aoyagi, Yuki Yoshimatsu, Yuji Tachimori, Ryoji Kushima, Tohru Kiyono, Masayuki Yamamoto
Format: Article
Language:English
Published: Elsevier 2011-09-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558611800382

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