Fast Dynamic in vivo Monitoring of Erk Activity at Single Cell Resolution in DREKA Zebrafish

Fast Dynamic in vivo Monitoring of Erk Activity at Single Cell Resolution in DREKA Zebrafish

Precise regulation of signaling pathways in single cells underlies tissue development, maintenance and repair in multicellular organisms, but our ability to monitor signaling dynamics in living vertebrates is currently limited. We implemented kinase translocation reporter (KTR) technology to create...

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Bibliographic Details
Main Authors: Vanessa Mayr, Caterina Sturtzel, Manuela Stadler, Sarah Grissenberger, Martin Distel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Zebrafish (Danio rerio)
signaling pathway activation
ERK activity dynamics
in vivo imaging
in vivo pharmacology
wounding
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2018.00111/full

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