Facial nerve ganglioneuroblastoma in a feline leukemia virus-positive cat

• Main Authors: Paula Reis Pereira, Nelson Junior Tagliari, Ronaldo Viana Leite-Filho, Gabriela da Cruz Schaefer, Fernanda Vieira Amorim da Costa, Saulo Petinatti Pavarini
• Format: Article
• Language: English
• Published: Universidade Federal de Santa Maria
• Series: Ciência Rural
• Subjects: neuronal neoplasm; cranial nerve VII; immunohistochemistry; feline leukemia virus.
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000500551&lng=en&tlng=en

ABSTRACT: Neuroblastic tumors can originate from the central neuraxis, olfactory epithelium, adrenal medullary region or autonomous system. Ganglioneuroblastoma are a type of neuroblastic tumor, with very few case descriptions in animals. Diagnosis of facial nerve ganglioneuroblastoma was made in a feline leukemia virus-positive 11-month-old cat. The cat had hyporexia, left head tilt, depressed mental state, horizontal nystagmus, inability to retract the pinched left lip, anisocoria, ptosis, and absence of the menace reflex. Gross necropsy showed a mass at the left facial nerve root region. Histological examination of this mass showed neoplastic proliferation of neuroblasts arranged in a cohesive pattern and mature ganglion cells. Ganglion cells were positive for neurofilament, neuron-specific enolase, S100, and glial fibrillary acidic protein by immunohistochemistry, while neuroblasts were positive for vimentin, S100, neuron-specific enolase and feline leukemia virus.