Recapitulating X-Linked Juvenile Retinoschisis in Mouse Model by Knock-In Patient-Specific Novel Mutation

Recapitulating X-Linked Juvenile Retinoschisis in Mouse Model by Knock-In Patient-Specific Novel Mutation

X-linked juvenile retinoschisis (XLRS) is a retinal disease caused by mutations in the gene encoding retinoschisin (RS1), which leads to a significant proportion of visual impairment and blindness. To develop personalized genome editing based gene therapy, knock-in animal disease models that have th...

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Bibliographic Details
Main Authors: Ding Chen, Tao Xu, Mengjun Tu, Jinlin Xu, Chenchen Zhou, Lulu Cheng, Ruqing Yang, Tanchu Yang, Weiwei Zheng, Xiubin He, Ruzhi Deng, Xianglian Ge, Jin Li, Zongming Song, Junzhao Zhao, Feng Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
retina
X-linked juvenile retinoschisis
knock-in
mice
disease model
genome editing technologies
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00453/full

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