The impact of preoperative trimetazidine use on oxidative parameters in patients undergoing coronary bypass surgery
Objective: This prospective, randomised, controlled,clinical study was planned to determine the effect oftrimetazidine on myocardial ischemia-reperfusion duringon pomp coronary artery bypass graft surgery (CABG).Methods: Thirty-five patients undergoing elective CABSin our hospital between 2008 and 2...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dicle University Medical School
2013-12-01
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| Series: | Dicle Medical Journal |
| Subjects: | |
| Online Access: | http://www.diclemedj.org/upload/sayi/29/Dicle%20Med%20J-01825.pdf |
| Summary: | Objective: This prospective, randomised, controlled,clinical study was planned to determine the effect oftrimetazidine on myocardial ischemia-reperfusion duringon pomp coronary artery bypass graft surgery (CABG).Methods: Thirty-five patients undergoing elective CABSin our hospital between 2008 and 2009 were included.The patients were divided into two groups randomly.Seventeen patients consisted trimetazidine group andpreoperative trimetazidine PO received for two weeks,whereas 18 cases were controls. Venous blood sampleswere drawn, preoperatively, intraoperatively and postoperatively,whereas coronary sinus blood samples weredrawn before and after cardiopulmonary bypass. At theend, total oxidative status (TOS) and total antioxidant status(TAS) were studied and oxidative stress index (OSİ)was calculated. Repeated measures analysis of variancewas used to test the influence of operative stress andtrimetazidine use on oxidative parameters.Results: Trimetazidine had no impact on total oxidativestatus, total antioxidant status and oxidative stress index(p>0.05). However, repeated measurements of total oxidativestatus, total antioxidant status and oxidative stressindex have revealed significant impact of operative stresson oxidative parameters (p<0.05).Conclusion: Preoperative trimetazidine use had no impacton total oxidative status, total antioxidant status andoxidative stress index contrary to significant influence ofoperative stress on oxidative parameters.Key words: Coronary bypass surgery, trimetazidine, oxidative stress |
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| ISSN: | 1300-2945 1308-9889 |