Neural Stem Cells Improve the Delivery of Oncolytic Chimeric Orthopoxvirus in a Metastatic Ovarian Cancer Model

Neural Stem Cells Improve the Delivery of Oncolytic Chimeric Orthopoxvirus in a Metastatic Ovarian Cancer Model

Oncolytic virotherapy represents a promising approach for treating recurrent and/or drug-resistant ovarian cancer. However, its successful application in the clinic has been hampered by rapid immune-mediated clearance, which reduces viral delivery to the tumor. Patient-derived mesenchymal stem cells...

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Bibliographic Details
Main Authors: Mohamed Hammad, Yvonne R. Cornejo, Jennifer Batalla-Covello, Asma Abdul Majid, Connor Burke, Zheng Liu, Yate-Ching Yuan, Min Li, Thanh H. Dellinger, Jianming Lu, Nanhai G. Chen, Yuman Fong, Karen S. Aboody, Rachael Mooney
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
oncolytic virotherapy
CF33
ovarian cancer
neural stem cells
cellular therapy
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520301066

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