Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery

Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery

A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of U...

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Main Authors: Gianfranco Decandia, Fabio Palumbo, Annalisa Treglia, Vincenza Armenise, Pietro Favia, Federico Baruzzi, Katrin Unger, Alberto Perrotta, Anna Maria Coclite
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Pharmaceutics
Subjects:
initiated chemical vapour deposition
drug delivery
poly(methyl methacrylate) (pmma) copolymer
antibacterial test
Online Access:https://www.mdpi.com/1999-4923/12/3/213
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spelling doaj-a515a25e5c494b288eed7893cfa7151d2020-11-25T00:32:38ZengMDPI AGPharmaceutics1999-49232020-03-0112321310.3390/pharmaceutics12030213pharmaceutics12030213Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin DeliveryGianfranco Decandia0Fabio Palumbo1Annalisa Treglia2Vincenza Armenise3Pietro Favia4Federico Baruzzi5Katrin Unger6Alberto Perrotta7Anna Maria Coclite8Department of Chemistry, University of Bari Aldo Moro, Via Orabona 4, 70126 Bari, ItalyInstitute of Nanotechnology, National Research Council of Italy, c/o Department of Chemistry, University of Bari Aldo Moro, Via Orabona 4, 70126 Bari, ItalyDepartment of Chemistry, University of Bari Aldo Moro, Via Orabona 4, 70126 Bari, ItalyDepartment of Chemistry, University of Bari Aldo Moro, Via Orabona 4, 70126 Bari, ItalyDepartment of Chemistry, University of Bari Aldo Moro, Via Orabona 4, 70126 Bari, ItalyInstitute of Sciences of Food Production, National Research Council of Italy, Via G. Amendola 122/O, 70126 Bari, ItalyInstitute of Solid State Physics, NAWI Graz, Graz University of Technology, Petersgasse 16, 8010 Graz, AustriaInstitute of Solid State Physics, NAWI Graz, Graz University of Technology, Petersgasse 16, 8010 Graz, AustriaInstitute of Solid State Physics, NAWI Graz, Graz University of Technology, Petersgasse 16, 8010 Graz, AustriaA coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete.https://www.mdpi.com/1999-4923/12/3/213initiated chemical vapour depositiondrug deliverypoly(methyl methacrylate) (pmma) copolymerantibacterial test
collection DOAJ
language English
format Article
sources DOAJ
author Gianfranco Decandia
Fabio Palumbo
Annalisa Treglia
Vincenza Armenise
Pietro Favia
Federico Baruzzi
Katrin Unger
Alberto Perrotta
Anna Maria Coclite
spellingShingle Gianfranco Decandia
Fabio Palumbo
Annalisa Treglia
Vincenza Armenise
Pietro Favia
Federico Baruzzi
Katrin Unger
Alberto Perrotta
Anna Maria Coclite
Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery
Pharmaceutics
initiated chemical vapour deposition
drug delivery
poly(methyl methacrylate) (pmma) copolymer
antibacterial test
author_facet Gianfranco Decandia
Fabio Palumbo
Annalisa Treglia
Vincenza Armenise
Pietro Favia
Federico Baruzzi
Katrin Unger
Alberto Perrotta
Anna Maria Coclite
author_sort Gianfranco Decandia
title Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery
title_short Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery
title_full Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery
title_fullStr Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery
title_full_unstemmed Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery
title_sort initiated chemical vapor deposition of crosslinked organic coatings for controlling gentamicin delivery
publisher MDPI AG
series Pharmaceutics
issn 1999-4923
publishDate 2020-03-01
description A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete.
topic initiated chemical vapour deposition
drug delivery
poly(methyl methacrylate) (pmma) copolymer
antibacterial test
url https://www.mdpi.com/1999-4923/12/3/213
work_keys_str_mv AT gianfrancodecandia initiatedchemicalvapordepositionofcrosslinkedorganiccoatingsforcontrollinggentamicindelivery
AT fabiopalumbo initiatedchemicalvapordepositionofcrosslinkedorganiccoatingsforcontrollinggentamicindelivery
AT annalisatreglia initiatedchemicalvapordepositionofcrosslinkedorganiccoatingsforcontrollinggentamicindelivery
AT vincenzaarmenise initiatedchemicalvapordepositionofcrosslinkedorganiccoatingsforcontrollinggentamicindelivery
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