Health related quality of life after extremely preterm birth: a matched controlled cohort study

<p>Abstract</p> <p>Background</p> <p>The majority of infants born before the last trimester now grow up. However, knowledge on subsequent health related quality of life (HRQoL) is scarce. We therefore aimed to compare HRQoL in children born extremely preterm with contro...

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Main Authors: Eide Geir E, Markestad Trond, Vederhus Bente J, Graue Marit, Halvorsen Thomas
Format: Article
Language:English
Published: BMC 2010-05-01
Series:Health and Quality of Life Outcomes
Online Access:http://www.hqlo.com/content/8/1/53
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spelling doaj-a514719bc76b4997be0eac10524926cf2020-11-24T21:16:05ZengBMCHealth and Quality of Life Outcomes1477-75252010-05-01815310.1186/1477-7525-8-53Health related quality of life after extremely preterm birth: a matched controlled cohort studyEide Geir EMarkestad TrondVederhus Bente JGraue MaritHalvorsen Thomas<p>Abstract</p> <p>Background</p> <p>The majority of infants born before the last trimester now grow up. However, knowledge on subsequent health related quality of life (HRQoL) is scarce. We therefore aimed to compare HRQoL in children born extremely preterm with control children born at term. Furthermore, we assessed HRQoL in relation to perinatal and neonatal morbidity and to current clinical and sociodemographic characteristics.</p> <p>Method</p> <p><it>The Child Health Questionnaire </it>(CHQ-PF50) and a general questionnaire were applied in a population based cohort of 10 year old children born at gestational age ≤ 28 weeks or with birth weight ≤ 1000 grams in Western Norway in 1991-92 and in term-born controls, individually matched for gender and time of birth. The McNemar test and paired t-tests were used to explore group differences between preterms and matched controls. Paired regression models and analyses of interaction (SPSS mixed linear model) were used to explore potential effects of sociodemographic and clinical characteristics on HRQoL in the two groups.</p> <p>Results</p> <p>All 35 eligible preterm children participated. None had major impairments. Learning and/or attention problems were present in 71% of preterms and 20% of controls (odds ratio (OR): 7.0; 95% confidence interval (CI): 2.2 to 27.6). Insufficient professional support was described by 36% of preterm vs. 3% of control parents (OR: infinite; CI: 2.7 to infinite). Preterms scored lower on eight CHQ-PF50 sub-scales and the two summary scores, boys accounting for most of the deficits in areas of behavior, psychosocial functioning and parental burden. HRQoL was associated with learning and/or attention problems in both preterm and control children, significantly more so in preterms in areas related to health and parental burden. Within the preterm group, HRQoL was mostly unrelated to perinatal and neonatal morbidity.</p> <p>Conclusions</p> <p>HRQoL for children born extremely preterm, and particularly for boys, was described by parents to be inferior to that of children born at term, and sufficiently poor to affect the daily life of the children and their families. Learning and/or attention problems were reported for a majority of preterms, strongly influencing their HRQoL.</p> http://www.hqlo.com/content/8/1/53
collection DOAJ
language English
format Article
sources DOAJ
author Eide Geir E
Markestad Trond
Vederhus Bente J
Graue Marit
Halvorsen Thomas
spellingShingle Eide Geir E
Markestad Trond
Vederhus Bente J
Graue Marit
Halvorsen Thomas
Health related quality of life after extremely preterm birth: a matched controlled cohort study
Health and Quality of Life Outcomes
author_facet Eide Geir E
Markestad Trond
Vederhus Bente J
Graue Marit
Halvorsen Thomas
author_sort Eide Geir E
title Health related quality of life after extremely preterm birth: a matched controlled cohort study
title_short Health related quality of life after extremely preterm birth: a matched controlled cohort study
title_full Health related quality of life after extremely preterm birth: a matched controlled cohort study
title_fullStr Health related quality of life after extremely preterm birth: a matched controlled cohort study
title_full_unstemmed Health related quality of life after extremely preterm birth: a matched controlled cohort study
title_sort health related quality of life after extremely preterm birth: a matched controlled cohort study
publisher BMC
series Health and Quality of Life Outcomes
issn 1477-7525
publishDate 2010-05-01
description <p>Abstract</p> <p>Background</p> <p>The majority of infants born before the last trimester now grow up. However, knowledge on subsequent health related quality of life (HRQoL) is scarce. We therefore aimed to compare HRQoL in children born extremely preterm with control children born at term. Furthermore, we assessed HRQoL in relation to perinatal and neonatal morbidity and to current clinical and sociodemographic characteristics.</p> <p>Method</p> <p><it>The Child Health Questionnaire </it>(CHQ-PF50) and a general questionnaire were applied in a population based cohort of 10 year old children born at gestational age ≤ 28 weeks or with birth weight ≤ 1000 grams in Western Norway in 1991-92 and in term-born controls, individually matched for gender and time of birth. The McNemar test and paired t-tests were used to explore group differences between preterms and matched controls. Paired regression models and analyses of interaction (SPSS mixed linear model) were used to explore potential effects of sociodemographic and clinical characteristics on HRQoL in the two groups.</p> <p>Results</p> <p>All 35 eligible preterm children participated. None had major impairments. Learning and/or attention problems were present in 71% of preterms and 20% of controls (odds ratio (OR): 7.0; 95% confidence interval (CI): 2.2 to 27.6). Insufficient professional support was described by 36% of preterm vs. 3% of control parents (OR: infinite; CI: 2.7 to infinite). Preterms scored lower on eight CHQ-PF50 sub-scales and the two summary scores, boys accounting for most of the deficits in areas of behavior, psychosocial functioning and parental burden. HRQoL was associated with learning and/or attention problems in both preterm and control children, significantly more so in preterms in areas related to health and parental burden. Within the preterm group, HRQoL was mostly unrelated to perinatal and neonatal morbidity.</p> <p>Conclusions</p> <p>HRQoL for children born extremely preterm, and particularly for boys, was described by parents to be inferior to that of children born at term, and sufficiently poor to affect the daily life of the children and their families. Learning and/or attention problems were reported for a majority of preterms, strongly influencing their HRQoL.</p>
url http://www.hqlo.com/content/8/1/53
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