Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization

Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization

Metastasis-initiating cells dynamically adapt to the distinct microenvironments of different organs, but these early adaptations are poorly understood due to the limited sensitivity of in situ transcriptomics. We developed fluorouracil-labeled RNA sequencing (Flura-seq) for in situ analysis with hig...

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Bibliographic Details
Main Authors: Harihar Basnet, Lin Tian, Karuna Ganesh, Yun-Han Huang, Danilo G Macalinao, Edi Brogi, Lydia WS Finley, Joan Massagué
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
In situ transcriptomics
oxidative stress
brain metastasis
lung metastasis
breast cancer
Online Access:https://elifesciences.org/articles/43627

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