In Vivo Follow-Up of Gene Inhibition in Solid Tumors Using Peptide-Based Nanoparticles for siRNA Delivery

In Vivo Follow-Up of Gene Inhibition in Solid Tumors Using Peptide-Based Nanoparticles for siRNA Delivery

Small interfering RNA (siRNA) exhibits a high degree of specificity for targeting selected genes. They are efficient on cells in vitro, but in vivo siRNA therapy remains a challenge for solid tumor treatment as siRNAs display difficulty reaching their intracellular target. The present study was desi...

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Bibliographic Details
Main Authors: Isabel Ferreiro, Coralie Genevois, Karidia Konate, Eric Vivès, Prisca Boisguérin, Sébastien Deshayes, Franck Couillaud
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
cancer therapy
siRNA
gene silencing
peptide-based nanoparticles
optical imaging
Online Access:https://www.mdpi.com/1999-4923/13/5/749

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