Synthesis of Mesoporous Silica Coated Gold Nanorods Loaded with Methylene Blue and Its Potentials in Antibacterial Applications

Synthesis of Mesoporous Silica Coated Gold Nanorods Loaded with Methylene Blue and Its Potentials in Antibacterial Applications

In this work, the successful preparation and characterization of gold nanorods (AuNRs) coated with a mesoporous silica shell (AuNRs@Simes) was achieved. Conjugation with methylene blue (MB) as a model drug using ultrasound-stimulated loading has been explored for further application in light-mediate...

Full description

Bibliographic Details
Main Authors: Adrián Fernández-Lodeiro, Jamila Djafari, Javier Fernández-Lodeiro, Maria Paula Duarte, Elisabete Muchagato Mauricio, José Luis Capelo-Martínez, Carlos Lodeiro
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Nanomaterials
Subjects:
mesoporous silica
gold nanorod
methylene blue
antibacterial activity
gold nanoparticles
Online Access:https://www.mdpi.com/2079-4991/11/5/1338
Description
Summary:In this work, the successful preparation and characterization of gold nanorods (AuNRs) coated with a mesoporous silica shell (AuNRs@Simes) was achieved. Conjugation with methylene blue (MB) as a model drug using ultrasound-stimulated loading has been explored for further application in light-mediated antibacterial studies. Lyophilization of this conjugated nanosystem was analyzed using trehalose (TRH) as a cryogenic protector. The obtained stable dry formulation shows potent antimicrobial activity against Gram-negative (<i>Escherichia coli</i>) and Gram-positive (<i>Staphylococcus aureus</i>) bacteria after a simple post-treatment irradiation method with a red laser during a short time period.
ISSN:2079-4991

Similar Items