Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis

Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis

HIF-1α is a pivotal protein involved in angiogenesis and is known to be regulated posttranslationally. Here, the authors show that HIF-1α is methylated by Set7/9 methyltransferase, which reduces protein stability and contributes to reduced angiogenesis.

Bibliographic Details
Main Authors: Yunho Kim, Hye Jin Nam, Junyeop Lee, Do Young Park, Chan Kim, Young Suk Yu, Dongha Kim, Se Won Park, Jinhyuk Bhin, Daehee Hwang, Ho Lee, Gou Young Koh, Sung Hee Baek
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10347
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spelling doaj-a4ea271d5fa347f9aabf818c7ba44cbe2021-05-11T11:00:10ZengNature Publishing GroupNature Communications2041-17232016-01-017111410.1038/ncomms10347Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesisYunho Kim0Hye Jin Nam1Junyeop Lee2Do Young Park3Chan Kim4Young Suk Yu5Dongha Kim6Se Won Park7Jinhyuk Bhin8Daehee Hwang9Ho Lee10Gou Young Koh11Sung Hee Baek12Creative Research Initiatives Center for Chromatin Dynamics, School of Biological Sciences, Seoul National UniversityCreative Research Initiatives Center for Chromatin Dynamics, School of Biological Sciences, Seoul National UniversityGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and TechnologyGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and TechnologyGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and TechnologyCreative Research Initiatives Center for Chromatin Dynamics, School of Biological Sciences, Seoul National UniversityCreative Research Initiatives Center for Chromatin Dynamics, School of Biological Sciences, Seoul National UniversityCreative Research Initiatives Center for Chromatin Dynamics, School of Biological Sciences, Seoul National UniversityDepartment of New Biology and Center for Plant Aging Research, Institute for Basic Science, DGISTDepartment of New Biology and Center for Plant Aging Research, Institute for Basic Science, DGISTGraduate School of Cancer Science and Policy, Research Institute, National Cancer CenterGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and TechnologyCreative Research Initiatives Center for Chromatin Dynamics, School of Biological Sciences, Seoul National UniversityHIF-1α is a pivotal protein involved in angiogenesis and is known to be regulated posttranslationally. Here, the authors show that HIF-1α is methylated by Set7/9 methyltransferase, which reduces protein stability and contributes to reduced angiogenesis.https://doi.org/10.1038/ncomms10347
collection DOAJ
language English
format Article
sources DOAJ
author Yunho Kim
Hye Jin Nam
Junyeop Lee
Do Young Park
Chan Kim
Young Suk Yu
Dongha Kim
Se Won Park
Jinhyuk Bhin
Daehee Hwang
Ho Lee
Gou Young Koh
Sung Hee Baek
spellingShingle Yunho Kim
Hye Jin Nam
Junyeop Lee
Do Young Park
Chan Kim
Young Suk Yu
Dongha Kim
Se Won Park
Jinhyuk Bhin
Daehee Hwang
Ho Lee
Gou Young Koh
Sung Hee Baek
Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
Nature Communications
author_facet Yunho Kim
Hye Jin Nam
Junyeop Lee
Do Young Park
Chan Kim
Young Suk Yu
Dongha Kim
Se Won Park
Jinhyuk Bhin
Daehee Hwang
Ho Lee
Gou Young Koh
Sung Hee Baek
author_sort Yunho Kim
title Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
title_short Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
title_full Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
title_fullStr Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
title_full_unstemmed Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
title_sort methylation-dependent regulation of hif-1α stability restricts retinal and tumour angiogenesis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-01-01
description HIF-1α is a pivotal protein involved in angiogenesis and is known to be regulated posttranslationally. Here, the authors show that HIF-1α is methylated by Set7/9 methyltransferase, which reduces protein stability and contributes to reduced angiogenesis.
url https://doi.org/10.1038/ncomms10347
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