Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
HIF-1α is a pivotal protein involved in angiogenesis and is known to be regulated posttranslationally. Here, the authors show that HIF-1α is methylated by Set7/9 methyltransferase, which reduces protein stability and contributes to reduced angiogenesis.
Bibliographic Details
| Main Authors: |
Yunho Kim,
Hye Jin Nam,
Junyeop Lee,
Do Young Park,
Chan Kim,
Young Suk Yu,
Dongha Kim,
Se Won Park,
Jinhyuk Bhin,
Daehee Hwang,
Ho Lee,
Gou Young Koh,
Sung Hee Baek |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2016-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms10347
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