HPLC-MS/MS Method for Quantitation of Sildenafil and Its Active Metabolite in Human Plasma

HPLC-MS/MS Method for Quantitation of Sildenafil and Its Active Metabolite in Human Plasma

A high demand for sildenafil-based drugs puts a premium on the development of methods for quantitation of sildenafil in bio-substrates to facilitate pharmacokinetic analysis in bioequivalence studies. High performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) was propo...

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Bibliographic Details
Main Authors:	G. G. Rodionov, I. I. Shantyr, I. E. Ushal, E. V. Svetkina, E. A. Kolobova, K. A. Zakharov
Format:	Article
Language:	Russian
Published:	OOO “Vashe Tsifrovoe Izdatelstvo” 2020-09-01
Series:	Ведомости Научного центра экспертизы средств медицинского применения
Subjects:	validation sildenafil n-desmethyl sildenafil bioequivalence hplc-ms/ms
Online Access:	https://www.vedomostincesmp.ru/jour/article/view/305

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