Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties

The cytoplasmic protein FROUNT can bind to chemokine receptors and enhance chemokine signalling. Here, the authors show that inhibiting FROUNT in macrophages either by knockdown of the gene or using the anti-alcoholism drug disulfiram, results in a reduction in tumour growth.

Bibliographic Details
Main Authors:	Yuya Terashima, Etsuko Toda, Meiji Itakura, Mikiya Otsuji, Sosuke Yoshinaga, Kazuhiro Okumura, Francis H. W. Shand, Yoshihiro Komohara, Mitsuhiro Takeda, Kana Kokubo, Ming-Chen Chen, Sana Yokoi, Hirofumi Rokutan, Yutaka Kofuku, Koji Ohnishi, Miki Ohira, Toshihiko Iizasa, Hirofumi Nakano, Takayoshi Okabe, Hirotatsu Kojima, Akira Shimizu, Shiro Kanegasaki, Ming-Rong Zhang, Ichio Shimada, Hiroki Nagase, Hiroaki Terasawa, Kouji Matsushima
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-14338-5

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spelling	doaj-a4d75cebbb8f47a985d666129063bb6d2021-05-11T09:07:24ZengNature Publishing GroupNature Communications2041-17232020-01-0111111610.1038/s41467-020-14338-5Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting propertiesYuya Terashima0Etsuko Toda1Meiji Itakura2Mikiya Otsuji3Sosuke Yoshinaga4Kazuhiro Okumura5Francis H. W. Shand6Yoshihiro Komohara7Mitsuhiro Takeda8Kana Kokubo9Ming-Chen Chen10Sana Yokoi11Hirofumi Rokutan12Yutaka Kofuku13Koji Ohnishi14Miki Ohira15Toshihiko Iizasa16Hirofumi Nakano17Takayoshi Okabe18Hirotatsu Kojima19Akira Shimizu20Shiro Kanegasaki21Ming-Rong Zhang22Ichio Shimada23Hiroki Nagase24Hiroaki Terasawa25Kouji Matsushima26Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences (RIBS), Tokyo University of ScienceDivision of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences (RIBS), Tokyo University of ScienceDepartment of Thoracic Disease, Chiba Cancer CenterDepartment of Molecular Preventive Medicine, Graduate School of Medicine, The University of TokyoDepartment of Structural BioImaging, Faculty of Life Sciences, Kumamoto UniversityChiba Cancer Center Research InstituteDepartment of Molecular Preventive Medicine, Graduate School of Medicine, The University of TokyoDepartment of Cell Pathology, Graduate School of Medical Sciences, Kumamoto UniversityDepartment of Structural BioImaging, Faculty of Life Sciences, Kumamoto UniversityDivision of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences (RIBS), Tokyo University of ScienceDivision of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences (RIBS), Tokyo University of ScienceChiba Cancer Center Research InstituteDepartment of Molecular Preventive Medicine, Graduate School of Medicine, The University of TokyoGraduate School of Pharmaceutical Sciences, The University of TokyoDepartment of Cell Pathology, Graduate School of Medical Sciences, Kumamoto UniversityChiba Cancer Center Research InstituteDepartment of Thoracic Disease, Chiba Cancer CenterDrug Discovery Initiative, The University of TokyoDrug Discovery Initiative, The University of TokyoDrug Discovery Initiative, The University of TokyoDepartment of Analytic Human Pathology, Nippon Medical SchoolResearch Institute, National Center for Global Health and MedicineDepartment of Radiopharmaceutics Development, National Institutes for Quantum and Radiological Science and TechnologyGraduate School of Pharmaceutical Sciences, The University of TokyoChiba Cancer Center Research InstituteDepartment of Structural BioImaging, Faculty of Life Sciences, Kumamoto UniversityDivision of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences (RIBS), Tokyo University of ScienceThe cytoplasmic protein FROUNT can bind to chemokine receptors and enhance chemokine signalling. Here, the authors show that inhibiting FROUNT in macrophages either by knockdown of the gene or using the anti-alcoholism drug disulfiram, results in a reduction in tumour growth.https://doi.org/10.1038/s41467-020-14338-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yuya Terashima Etsuko Toda Meiji Itakura Mikiya Otsuji Sosuke Yoshinaga Kazuhiro Okumura Francis H. W. Shand Yoshihiro Komohara Mitsuhiro Takeda Kana Kokubo Ming-Chen Chen Sana Yokoi Hirofumi Rokutan Yutaka Kofuku Koji Ohnishi Miki Ohira Toshihiko Iizasa Hirofumi Nakano Takayoshi Okabe Hirotatsu Kojima Akira Shimizu Shiro Kanegasaki Ming-Rong Zhang Ichio Shimada Hiroki Nagase Hiroaki Terasawa Kouji Matsushima
spellingShingle	Yuya Terashima Etsuko Toda Meiji Itakura Mikiya Otsuji Sosuke Yoshinaga Kazuhiro Okumura Francis H. W. Shand Yoshihiro Komohara Mitsuhiro Takeda Kana Kokubo Ming-Chen Chen Sana Yokoi Hirofumi Rokutan Yutaka Kofuku Koji Ohnishi Miki Ohira Toshihiko Iizasa Hirofumi Nakano Takayoshi Okabe Hirotatsu Kojima Akira Shimizu Shiro Kanegasaki Ming-Rong Zhang Ichio Shimada Hiroki Nagase Hiroaki Terasawa Kouji Matsushima Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties Nature Communications
author_facet	Yuya Terashima Etsuko Toda Meiji Itakura Mikiya Otsuji Sosuke Yoshinaga Kazuhiro Okumura Francis H. W. Shand Yoshihiro Komohara Mitsuhiro Takeda Kana Kokubo Ming-Chen Chen Sana Yokoi Hirofumi Rokutan Yutaka Kofuku Koji Ohnishi Miki Ohira Toshihiko Iizasa Hirofumi Nakano Takayoshi Okabe Hirotatsu Kojima Akira Shimizu Shiro Kanegasaki Ming-Rong Zhang Ichio Shimada Hiroki Nagase Hiroaki Terasawa Kouji Matsushima
author_sort	Yuya Terashima
title	Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties
title_short	Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties
title_full	Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties
title_fullStr	Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties
title_full_unstemmed	Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties
title_sort	targeting frount with disulfiram suppresses macrophage accumulation and its tumor-promoting properties
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-01-01
description	The cytoplasmic protein FROUNT can bind to chemokine receptors and enhance chemokine signalling. Here, the authors show that inhibiting FROUNT in macrophages either by knockdown of the gene or using the anti-alcoholism drug disulfiram, results in a reduction in tumour growth.
url	https://doi.org/10.1038/s41467-020-14338-5
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Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties

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