Effect of small-dose ketamine combined with dexmedetomidine on emergence stress response as well as postoperative pain and Th cell deviation in patients with cervical cancer surgery under general anesthesian

• Main Authors: Jin-Wen Gao, Mei-Yu Lin, Qun-Fei Zou, Jie-Lian Huang, Ming-Xiong Cheng
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-04-01
• Series: Journal of Hainan Medical University
• Subjects: Cervical cancer Ketamine Dexmedetomidine Stress Pain Immune response
• Online Access: http://www.hnykdxxb.com/PDF/201708/18.pdf

Objective: To study the effect of small-dose ketamine combined with dexmedetomidine on emergence stress response as well as postoperative pain and Th cell deviation in patients with cervical cancer surgery under general anesthesia. Methods: A total of 136 patients who received radical operation for cervical cancer in our hospital between May 2013 and May 2016 were selected and randomly divided into control group, dexmedetomidine group (Dex), ketamine group (Ket group) and combined group, and serum was collected to determine the levels of stress hormones, pain mediators and Th cytokines. Results: During anesthesia recovery, serum NE, E, Cor, Ins and C-P levels of combined group, Dex group and Ket group were significantly lower than those of control group, and serum NE, E, Cor, Ins and C-P levels of combined group were significantly lower than those of Dex group and Ket group; after surgery, serum SP, PGE2, β-EP, NO, IL-4, IL-5 and IL-10 levels of combined group, Dex group and Ket group were significantly lower than those of control group while IL-2, TNF-α and IFN-γ levels were significantly higher than those of control group, and serum SP, PGE2, β-EP, NO, IL-4, IL-5 and IL-10 levels of combined group were significantly lower than those of Dex group and Ket group while IL-2, TNF-α and IFN-γ levels were significantly higher than those of Dex group and Ket group. Conclusion: Small-dose ketamine combined with dexmedetomidine can more effectively reduce emergence stress response and postoperative pain, and improve Th cell deviation than single drug intervention.