PTPσ inhibitors promote hematopoietic stem cell regeneration

Protein tyrosine phosphatase sigma (PTPσ) deficient haematopoietic stem cells (HSCs) demonstrate increased engraftment following transplantation. Here the authors identify a small molecule inhibitor of PTPσ that promotes murine and human haematopoietic stem cell regeneration via induction of the RAC...

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Main Authors:	Yurun Zhang, Martina Roos, Heather Himburg, Christina M. Termini, Mamle Quarmyne, Michelle Li, Liman Zhao, Jenny Kan, Tiancheng Fang, Xiao Yan, Katherine Pohl, Emelyne Diers, Hyo Jin Gim, Robert Damoiseaux, Julian Whitelegge, William McBride, Michael E. Jung, John P. Chute
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11490-5

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spelling	doaj-a4cd7b0d3b6b453f9917108aabe1cec22021-05-11T11:38:25ZengNature Publishing GroupNature Communications2041-17232019-08-0110111510.1038/s41467-019-11490-5PTPσ inhibitors promote hematopoietic stem cell regenerationYurun Zhang0Martina Roos1Heather Himburg2Christina M. Termini3Mamle Quarmyne4Michelle Li5Liman Zhao6Jenny Kan7Tiancheng Fang8Xiao Yan9Katherine Pohl10Emelyne Diers11Hyo Jin Gim12Robert Damoiseaux13Julian Whitelegge14William McBride15Michael E. Jung16John P. Chute17Molecular Biology Institute, University of California, Los Angeles (UCLA)Division of Hematology/Oncology, Department of Medicine, UCLADivision of Hematology/Oncology, Department of Medicine, UCLADivision of Hematology/Oncology, Department of Medicine, UCLADivision of Hematology/Oncology, Department of Medicine, UCLADivision of Hematology/Oncology, Department of Medicine, UCLADivision of Hematology/Oncology, Department of Medicine, UCLADivision of Hematology/Oncology, Department of Medicine, UCLADivision of Hematology/Oncology, Department of Medicine, UCLADivision of Hematology/Oncology, Department of Medicine, UCLADivision of Hematology/Oncology, Department of Medicine, UCLADepartment of Chemistry and Biochemistry, UCLADepartment of Chemistry and Biochemistry, UCLAJonsson Comprehensive Cancer Center, UCLADepartment of Psychiatry and Behavioral Sciences, UCLAJonsson Comprehensive Cancer Center, UCLADepartment of Chemistry and Biochemistry, UCLADivision of Hematology/Oncology, Department of Medicine, UCLAProtein tyrosine phosphatase sigma (PTPσ) deficient haematopoietic stem cells (HSCs) demonstrate increased engraftment following transplantation. Here the authors identify a small molecule inhibitor of PTPσ that promotes murine and human haematopoietic stem cell regeneration via induction of the RAC pathway and BCL-XL.https://doi.org/10.1038/s41467-019-11490-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yurun Zhang Martina Roos Heather Himburg Christina M. Termini Mamle Quarmyne Michelle Li Liman Zhao Jenny Kan Tiancheng Fang Xiao Yan Katherine Pohl Emelyne Diers Hyo Jin Gim Robert Damoiseaux Julian Whitelegge William McBride Michael E. Jung John P. Chute
spellingShingle	Yurun Zhang Martina Roos Heather Himburg Christina M. Termini Mamle Quarmyne Michelle Li Liman Zhao Jenny Kan Tiancheng Fang Xiao Yan Katherine Pohl Emelyne Diers Hyo Jin Gim Robert Damoiseaux Julian Whitelegge William McBride Michael E. Jung John P. Chute PTPσ inhibitors promote hematopoietic stem cell regeneration Nature Communications
author_facet	Yurun Zhang Martina Roos Heather Himburg Christina M. Termini Mamle Quarmyne Michelle Li Liman Zhao Jenny Kan Tiancheng Fang Xiao Yan Katherine Pohl Emelyne Diers Hyo Jin Gim Robert Damoiseaux Julian Whitelegge William McBride Michael E. Jung John P. Chute
author_sort	Yurun Zhang
title	PTPσ inhibitors promote hematopoietic stem cell regeneration
title_short	PTPσ inhibitors promote hematopoietic stem cell regeneration
title_full	PTPσ inhibitors promote hematopoietic stem cell regeneration
title_fullStr	PTPσ inhibitors promote hematopoietic stem cell regeneration
title_full_unstemmed	PTPσ inhibitors promote hematopoietic stem cell regeneration
title_sort	ptpσ inhibitors promote hematopoietic stem cell regeneration
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-08-01
description	Protein tyrosine phosphatase sigma (PTPσ) deficient haematopoietic stem cells (HSCs) demonstrate increased engraftment following transplantation. Here the authors identify a small molecule inhibitor of PTPσ that promotes murine and human haematopoietic stem cell regeneration via induction of the RAC pathway and BCL-XL.
url	https://doi.org/10.1038/s41467-019-11490-5
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PTPσ inhibitors promote hematopoietic stem cell regeneration

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