A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks

A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks

DNA double strand breaks (DSBs) are among the most deleterious types of damage and there is strong evidence indicating a relationship between breaks and transcription. Here the authors provide a high-resolution, genome-wide map of induced DSBs and observe ATM-dependent transcriptional repression.

Bibliographic Details
Main Authors: Fabio Iannelli, Alessandro Galbiati, Ilaria Capozzo, Quan Nguyen, Brian Magnuson, Flavia Michelini, Giuseppina D’Alessandro, Matteo Cabrini, Marco Roncador, Sofia Francia, Nicola Crosetto, Mats Ljungman, Piero Carninci, Fabrizio d’Adda di Fagagna
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15656
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spelling doaj-a4cc05be64fb4756ab65972047e8495b2021-05-11T07:26:12ZengNature Publishing GroupNature Communications2041-17232017-05-018111210.1038/ncomms15656A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaksFabio Iannelli0Alessandro Galbiati1Ilaria Capozzo2Quan Nguyen3Brian Magnuson4Flavia Michelini5Giuseppina D’Alessandro6Matteo Cabrini7Marco Roncador8Sofia Francia9Nicola Crosetto10Mats Ljungman11Piero Carninci12Fabrizio d’Adda di Fagagna13IFOM, The FIRC Institute of Molecular OncologyIFOM, The FIRC Institute of Molecular OncologyIGM (Istituto di Genetica Molecolare)-CNR (Consiglio Nazionale delle Ricerche)Division of Genomic Technologies, RIKEN Center for Life Science TechnologiesDepartment of Radiation Oncology, University of MichiganIFOM, The FIRC Institute of Molecular OncologyIFOM, The FIRC Institute of Molecular OncologyIGM (Istituto di Genetica Molecolare)-CNR (Consiglio Nazionale delle Ricerche)IGM (Istituto di Genetica Molecolare)-CNR (Consiglio Nazionale delle Ricerche)IFOM, The FIRC Institute of Molecular OncologyDivision of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska InstitutetDepartment of Radiation Oncology, University of MichiganDivision of Genomic Technologies, RIKEN Center for Life Science TechnologiesIFOM, The FIRC Institute of Molecular OncologyDNA double strand breaks (DSBs) are among the most deleterious types of damage and there is strong evidence indicating a relationship between breaks and transcription. Here the authors provide a high-resolution, genome-wide map of induced DSBs and observe ATM-dependent transcriptional repression.https://doi.org/10.1038/ncomms15656
collection DOAJ
language English
format Article
sources DOAJ
author Fabio Iannelli
Alessandro Galbiati
Ilaria Capozzo
Quan Nguyen
Brian Magnuson
Flavia Michelini
Giuseppina D’Alessandro
Matteo Cabrini
Marco Roncador
Sofia Francia
Nicola Crosetto
Mats Ljungman
Piero Carninci
Fabrizio d’Adda di Fagagna
spellingShingle Fabio Iannelli
Alessandro Galbiati
Ilaria Capozzo
Quan Nguyen
Brian Magnuson
Flavia Michelini
Giuseppina D’Alessandro
Matteo Cabrini
Marco Roncador
Sofia Francia
Nicola Crosetto
Mats Ljungman
Piero Carninci
Fabrizio d’Adda di Fagagna
A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
Nature Communications
author_facet Fabio Iannelli
Alessandro Galbiati
Ilaria Capozzo
Quan Nguyen
Brian Magnuson
Flavia Michelini
Giuseppina D’Alessandro
Matteo Cabrini
Marco Roncador
Sofia Francia
Nicola Crosetto
Mats Ljungman
Piero Carninci
Fabrizio d’Adda di Fagagna
author_sort Fabio Iannelli
title A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
title_short A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
title_full A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
title_fullStr A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
title_full_unstemmed A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
title_sort damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped dna double-strand breaks
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-05-01
description DNA double strand breaks (DSBs) are among the most deleterious types of damage and there is strong evidence indicating a relationship between breaks and transcription. Here the authors provide a high-resolution, genome-wide map of induced DSBs and observe ATM-dependent transcriptional repression.
url https://doi.org/10.1038/ncomms15656
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