A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
DNA double strand breaks (DSBs) are among the most deleterious types of damage and there is strong evidence indicating a relationship between breaks and transcription. Here the authors provide a high-resolution, genome-wide map of induced DSBs and observe ATM-dependent transcriptional repression.
Bibliographic Details
| Main Authors: |
Fabio Iannelli,
Alessandro Galbiati,
Ilaria Capozzo,
Quan Nguyen,
Brian Magnuson,
Flavia Michelini,
Giuseppina D’Alessandro,
Matteo Cabrini,
Marco Roncador,
Sofia Francia,
Nicola Crosetto,
Mats Ljungman,
Piero Carninci,
Fabrizio d’Adda di Fagagna |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms15656
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