Genomic Profile and BRCA-1 Promoter Methylation Status in BRCA Mutated Ovarian Cancer: New Insights in Predictive Biomarkers of Olaparib Response

Genomic Profile and BRCA-1 Promoter Methylation Status in BRCA Mutated Ovarian Cancer: New Insights in Predictive Biomarkers of Olaparib Response

Objective: We assessed the genomic profile of four representative BRCA-mutated ovarian cancer (OC) patients treated with olaparib to investigate the relationship between intratumor heterogeneity and response to olaparib treatment. The main aim is to identify possible predictive biomarkers of respons...

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Bibliographic Details
Main Authors: Elisena Franzese, Sara Centonze, Anna Diana, Angela Lombardi, Francesca Carlino, Luigi Pio Guerrera, Ferdinando De Vita, Michele Caraglia, Sandro Pignata, Fortunato Ciardiello, Michele Orditura
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Oncology
Subjects:
ovarian cancer
genomic profiles
BRCA 1/2 mutation carriers
promoter methylation
olaparib (Lynparza™)
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01289/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.01289/full

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