The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65
Background Subclinical hypothyroidism (SCH) is the most common thyroid dysfunction, and its relationship with blood pressure (BP) has been controversial. The aim of the study was to analyze the association between SCH and newly-diagnosed hypertension. Methods Based on data from the Thyroid disease,...
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| Format: | Article |
| Language: | English |
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Academya Publishing Co.
2021-08-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.e-enm.org/upload/pdf/enm-2021-1101.pdf |
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DOAJ |
| language |
English |
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Article |
| sources |
DOAJ |
| author |
Xichang Wang Haoyu Wang Li Yan Lihui Yang Yuanming Xue Jing Yang Yongli Yao Xulei Tang Nanwei Tong Guixia Wang Jinan Zhang Youmin Wang Jianming Ba Bing Chen Jianling Du Lanjie He Xiaoyang Lai Yanbo Li Zhaoli Yan Eryuan Liao Chao Liu Libin Liu Guijun Qin Yingfen Qin Huibiao Quan Bingyin Shi Hui Sun Zhen Ye Qiao Zhang Lihui Zhang Jun Zhu Mei Zhu Yongze Li Weiping Teng Zhongyan Shan |
| spellingShingle |
Xichang Wang Haoyu Wang Li Yan Lihui Yang Yuanming Xue Jing Yang Yongli Yao Xulei Tang Nanwei Tong Guixia Wang Jinan Zhang Youmin Wang Jianming Ba Bing Chen Jianling Du Lanjie He Xiaoyang Lai Yanbo Li Zhaoli Yan Eryuan Liao Chao Liu Libin Liu Guijun Qin Yingfen Qin Huibiao Quan Bingyin Shi Hui Sun Zhen Ye Qiao Zhang Lihui Zhang Jun Zhu Mei Zhu Yongze Li Weiping Teng Zhongyan Shan The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65 Endocrinology and Metabolism hypothyroidism blood pressure hypertension |
| author_facet |
Xichang Wang Haoyu Wang Li Yan Lihui Yang Yuanming Xue Jing Yang Yongli Yao Xulei Tang Nanwei Tong Guixia Wang Jinan Zhang Youmin Wang Jianming Ba Bing Chen Jianling Du Lanjie He Xiaoyang Lai Yanbo Li Zhaoli Yan Eryuan Liao Chao Liu Libin Liu Guijun Qin Yingfen Qin Huibiao Quan Bingyin Shi Hui Sun Zhen Ye Qiao Zhang Lihui Zhang Jun Zhu Mei Zhu Yongze Li Weiping Teng Zhongyan Shan |
| author_sort |
Xichang Wang |
| title |
The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65 |
| title_short |
The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65 |
| title_full |
The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65 |
| title_fullStr |
The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65 |
| title_full_unstemmed |
The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65 |
| title_sort |
positive association between subclinical hypothyroidism and newly-diagnosed hypertension is more explicit in female individuals younger than 65 |
| publisher |
Academya Publishing Co. |
| series |
Endocrinology and Metabolism |
| issn |
2093-596X 2093-5978 |
| publishDate |
2021-08-01 |
| description |
Background Subclinical hypothyroidism (SCH) is the most common thyroid dysfunction, and its relationship with blood pressure (BP) has been controversial. The aim of the study was to analyze the association between SCH and newly-diagnosed hypertension. Methods Based on data from the Thyroid disease, Iodine nutrition and Diabetes Epidemiology (TIDE) study, 49,433 euthyroid individuals and 7,719 SCH patients aged ≥18 years were enrolled. Patients with a history of hypertension or thyroid disease were excluded. SCH was determined by manufacturer reference range. Overall hypertension and stage 1 and 2 hypertension were diagnosed according to the guidelines issued by the American College of Cardiology/American Heart Association in 2017. Results The prevalence of overall hypertension (48.7%), including stage 1 (28.9%) and 2 (19.8%) hypertension, increased significantly in SCH patients compared with euthyroid subjects. With elevated serum thyroid stimulating hormone (TSH) level, the hypertension prevalence also increased significantly from the euthyroid to different SCH subgroups, which was more profound in females or subjects aged <65 years. The age- and sex-specific regression analysis further demonstrated the same trends in the general population and in the 1:1 propensity matched population. Similarly, several BP components (i.e., systolic, diastolic, and mean arterial BP) were positively associated with TSH elevation, and regression analysis also confirmed that all BP components were closely related with SCH in female subjects aged <65 years. Conclusion The prevalence of hypertension increases for patients with SCH. SCH tends to be associated with hypertension and BP components in females younger than 65 years. |
| topic |
hypothyroidism blood pressure hypertension |
| url |
http://www.e-enm.org/upload/pdf/enm-2021-1101.pdf |
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doaj-a4ad81c6df43467293ab5a9383fc5f0f2021-09-03T00:03:20ZengAcademya Publishing Co.Endocrinology and Metabolism2093-596X2093-59782021-08-0136477878910.3803/EnM.2021.11012196The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65Xichang Wang0Haoyu Wang1Li Yan2Lihui Yang3Yuanming Xue4Jing Yang5Yongli Yao6Xulei Tang7Nanwei Tong8Guixia Wang9Jinan Zhang10Youmin Wang11Jianming Ba12Bing Chen13Jianling Du14Lanjie He15Xiaoyang Lai16Yanbo Li17Zhaoli Yan18Eryuan Liao19Chao Liu20Libin Liu21Guijun Qin22Yingfen Qin23Huibiao Quan24Bingyin Shi25Hui Sun26Zhen Ye27Qiao Zhang28Lihui Zhang29Jun Zhu30Mei Zhu31Yongze Li32Weiping Teng33Zhongyan Shan34 Department of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China Department of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China Department of Endocrinology and Metabolism, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China Department of Endocrinology and Metabolism, People’s Hospital of the Tibet Autonomous Region, Lhasa, Tibet, China Department of Endocrinology, The First People’s Hospital of Yunnan Province, Kunming, China Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, China Department of Endocrinology, Qinghai Provincial People’s Hospital, Xining, China Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, China Department of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China Department of Endocrinology, Health Science Affiliated Zhoupu Hosipital, Shanghai University of Medicine, Shanghai, China Department of Endocrinology, The First Hospital of An Hui Medical University, Hefei, China Department of Endocrinology, Chinese PLA General Hospital, Beijing, China Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing, China Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, China Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital of Ningxia Medical University, Yinchuan, China Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China Department of Endocrinology, The Affiliated Hospital of Inner Mongolia Medical University. Hohhot, China Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China Research Center of Endocrine and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China Department of Endocrine, First Affiliated Hospital of Guangxi Medical University, Nanning, China Department of Endocrinology, Hainan General Hospital, Haikou, China Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China Department of Endocrinology and Metabolism, Affiliated Hospital of Guiyang Medical University, Guiyang, China Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, China Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China Department of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China Department of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China Department of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, ChinaBackground Subclinical hypothyroidism (SCH) is the most common thyroid dysfunction, and its relationship with blood pressure (BP) has been controversial. The aim of the study was to analyze the association between SCH and newly-diagnosed hypertension. Methods Based on data from the Thyroid disease, Iodine nutrition and Diabetes Epidemiology (TIDE) study, 49,433 euthyroid individuals and 7,719 SCH patients aged ≥18 years were enrolled. Patients with a history of hypertension or thyroid disease were excluded. SCH was determined by manufacturer reference range. Overall hypertension and stage 1 and 2 hypertension were diagnosed according to the guidelines issued by the American College of Cardiology/American Heart Association in 2017. Results The prevalence of overall hypertension (48.7%), including stage 1 (28.9%) and 2 (19.8%) hypertension, increased significantly in SCH patients compared with euthyroid subjects. With elevated serum thyroid stimulating hormone (TSH) level, the hypertension prevalence also increased significantly from the euthyroid to different SCH subgroups, which was more profound in females or subjects aged <65 years. The age- and sex-specific regression analysis further demonstrated the same trends in the general population and in the 1:1 propensity matched population. Similarly, several BP components (i.e., systolic, diastolic, and mean arterial BP) were positively associated with TSH elevation, and regression analysis also confirmed that all BP components were closely related with SCH in female subjects aged <65 years. Conclusion The prevalence of hypertension increases for patients with SCH. SCH tends to be associated with hypertension and BP components in females younger than 65 years.http://www.e-enm.org/upload/pdf/enm-2021-1101.pdfhypothyroidismblood pressurehypertension |