Synthesis of 3-aminocoumarin-N-benzylpyridinium conjugates with nanomolar inhibitory activity against acetylcholinesterase

Synthesis of 3-aminocoumarin-N-benzylpyridinium conjugates with nanomolar inhibitory activity against acetylcholinesterase

A series of 3-amino-6,7-dimethoxycoumarins conjugated with the N-benzylpyridinium moiety through an amide-bond linkage was synthesized and evaluated for their acetylcholinesterase inhibitory activity. A number of the benzylpyridinium derivatives exhibited potent activities with inhibitory concentrat...

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Bibliographic Details
Main Authors:	Nisachon Khunnawutmanotham, Cherdchai Laongthipparos, Patchreenart Saparpakorn, Nitirat Chimnoi, Supanna Techasakul
Format:	Article
Language:	English
Published:	Beilstein-Institut 2018-10-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	acetylcholinesterase inhibitor 3-aminocoumarin N-benzylpyridinium dual binding site inhibitor synthesis
Online Access:	https://doi.org/10.3762/bjoc.14.231

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