STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth

Summary: Citrate is a required carbon precursor for de novo fatty acid and membrane lipid synthesis. However, the pathways regulating intracellular citrate, particularly during the initial transition from a resting state to cell growth, remain unclear. Here, we show that STAT3 is among the first sig...

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Bibliographic Details
Main Authors: Sarah MacPherson, Michael Horkoff, Cleo Gravel, Thomas Hoffmann, Johannes Zuber, Julian J. Lum
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717304874