Therapy for myocardial infarction: In vitro and in vivo evaluation of puerarin-prodrug and tanshinone co-loaded lipid nanoparticulate system

Therapy for myocardial infarction: In vitro and in vivo evaluation of puerarin-prodrug and tanshinone co-loaded lipid nanoparticulate system

Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide. Nanoparticle systems carrying drugs have already been developed to treat MI. To improve the efficiency of tanshinone (TAN), and to achieve the synergistic effect of TAN and puerarin (PUE), PUE-prodrug and TAN co-lo...

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Bibliographic Details
Main Authors: Jing Guo, Xiaowei Xing, Na Lv, Jingjie Zhao, Yusheng Liu, Huiping Gong, Yimeng Du, Qinghua Lu, Zhaoqiang Dong
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Myocardial infarction
Prodrug
Solid lipid nanoparticles
Puerarin
Tanshinone
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219332858

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http://www.sciencedirect.com/science/article/pii/S0753332219332858

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