Werner Syndrome
Werner syndrome is a premature aging disease caused by the mutation in the WRN gene. The cloning and characterization of the WRN gene and its product allows investigators to study the disease and the human aging process at molecular level. This review summarizes the recent progresses on various aspe...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2002-01-01
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| Series: | Journal of Biomedicine and Biotechnology |
| Online Access: | http://dx.doi.org/10.1155/S1110724302201011 |
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doaj-a4a17987de8d445ca3922193095b01b22020-11-24T22:09:24ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512002-01-0122465410.1155/S1110724302201011Werner SyndromeLishan Chen0Junko Oshima1Department of Pathology, Box 357470, HSB K-543, University of Washington, Seattle 98195-7470, WA, USADepartment of Pathology, Box 357470, HSB K-543, University of Washington, Seattle 98195-7470, WA, USAWerner syndrome is a premature aging disease caused by the mutation in the WRN gene. The cloning and characterization of the WRN gene and its product allows investigators to study the disease and the human aging process at molecular level. This review summarizes the recent progresses on various aspects of the WRN research including functional analysis of the protein, interactive cloning, complexes formation, mouse models, and SNPs (single nucleotide polymorphisms). These in depth investigations have greatly advanced our understanding of the disease and elucidated future research direction for Werner syndrome and the human aging process.http://dx.doi.org/10.1155/S1110724302201011 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Lishan Chen Junko Oshima |
| spellingShingle |
Lishan Chen Junko Oshima Werner Syndrome Journal of Biomedicine and Biotechnology |
| author_facet |
Lishan Chen Junko Oshima |
| author_sort |
Lishan Chen |
| title |
Werner Syndrome |
| title_short |
Werner Syndrome |
| title_full |
Werner Syndrome |
| title_fullStr |
Werner Syndrome |
| title_full_unstemmed |
Werner Syndrome |
| title_sort |
werner syndrome |
| publisher |
Hindawi Limited |
| series |
Journal of Biomedicine and Biotechnology |
| issn |
1110-7243 1110-7251 |
| publishDate |
2002-01-01 |
| description |
Werner syndrome is a premature aging disease caused by the
mutation in the WRN gene. The cloning and
characterization of the WRN gene and its product allows
investigators to study the disease and the human aging process at
molecular level. This review summarizes the recent progresses on
various aspects of the WRN research including functional
analysis of the protein, interactive cloning, complexes
formation, mouse models, and SNPs (single nucleotide
polymorphisms). These in depth investigations have greatly
advanced our understanding of the disease and elucidated future
research direction for Werner syndrome and the human aging
process. |
| url |
http://dx.doi.org/10.1155/S1110724302201011 |
| work_keys_str_mv |
AT lishanchen wernersyndrome AT junkooshima wernersyndrome |
| _version_ |
1725812026645676032 |