Werner Syndrome
Werner syndrome is a premature aging disease caused by the mutation in the WRN gene. The cloning and characterization of the WRN gene and its product allows investigators to study the disease and the human aging process at molecular level. This review summarizes the recent progresses on various aspe...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2002-01-01
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| Series: | Journal of Biomedicine and Biotechnology |
| Online Access: | http://dx.doi.org/10.1155/S1110724302201011 |
| Summary: | Werner syndrome is a premature aging disease caused by the
mutation in the WRN gene. The cloning and
characterization of the WRN gene and its product allows
investigators to study the disease and the human aging process at
molecular level. This review summarizes the recent progresses on
various aspects of the WRN research including functional
analysis of the protein, interactive cloning, complexes
formation, mouse models, and SNPs (single nucleotide
polymorphisms). These in depth investigations have greatly
advanced our understanding of the disease and elucidated future
research direction for Werner syndrome and the human aging
process. |
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| ISSN: | 1110-7243 1110-7251 |