A suppository-base-matrix tablet for time-dependent colon-specific delivery system

Our research has focused on the main design features and release performances of time-dependent colon-specific (TDCS) delivery tablets, which relies on the relative constancy that is observed in the small intestinal transit time of dosage forms. But inflammatory bowel disease(IBD)can affect the tran...

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Main Authors: Meijuan Zou, Caixia Wang, Xuezhu Zhang, Tao Xu, Jiarong Han, Xiao Zhang, Gang Cheng
Format: Article
Language:English
Published: Universidade de São Paulo 2014-09-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300535&lng=en&tlng=en
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spelling doaj-a4a0b06478ec45699a435cfc157f81682020-11-24T20:47:29ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902014-09-0150353554110.1590/S1984-82502014000300012S1984-82502014000300535A suppository-base-matrix tablet for time-dependent colon-specific delivery systemMeijuan ZouCaixia WangXuezhu ZhangTao XuJiarong HanXiao ZhangGang ChengOur research has focused on the main design features and release performances of time-dependent colon-specific (TDCS) delivery tablets, which relies on the relative constancy that is observed in the small intestinal transit time of dosage forms. But inflammatory bowel disease(IBD)can affect the transit time, and usually results in watery stool. Compared to the TDCS and wax-matrix TDCS tablet, a promising time-dependent colon-specific delivery system was investigated. In our study, a suppository-base-matrix coated tablet was evaluated. Water soluble suppository-base helps the expansion of tablet, facilitates uniform film dissolution and achives high osmotic pressure. Combining the expansion of carboxymethyl starch sodium (CMS-Na) and the moisture absorption of NaCl, the coated TDCS tablet obtained a burst and targeted drug delivery system. A very good correlation between in vitro drug release and in vivo outcome was observed. This TDCS coated tablet provides a promising strategy to control drug release to the desired lower gastrointestinal region.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300535&lng=en&tlng=enDoença inflamatória do intestinoLonicera japonica Thunb./extratoSupositório/liberação cólon-específicaFármaco/liberação cólon-específicaComprimidos/revestidos/liberação cólon específica
collection DOAJ
language English
format Article
sources DOAJ
author Meijuan Zou
Caixia Wang
Xuezhu Zhang
Tao Xu
Jiarong Han
Xiao Zhang
Gang Cheng
spellingShingle Meijuan Zou
Caixia Wang
Xuezhu Zhang
Tao Xu
Jiarong Han
Xiao Zhang
Gang Cheng
A suppository-base-matrix tablet for time-dependent colon-specific delivery system
Brazilian Journal of Pharmaceutical Sciences
Doença inflamatória do intestino
Lonicera japonica Thunb./extrato
Supositório/liberação cólon-específica
Fármaco/liberação cólon-específica
Comprimidos/revestidos/liberação cólon específica
author_facet Meijuan Zou
Caixia Wang
Xuezhu Zhang
Tao Xu
Jiarong Han
Xiao Zhang
Gang Cheng
author_sort Meijuan Zou
title A suppository-base-matrix tablet for time-dependent colon-specific delivery system
title_short A suppository-base-matrix tablet for time-dependent colon-specific delivery system
title_full A suppository-base-matrix tablet for time-dependent colon-specific delivery system
title_fullStr A suppository-base-matrix tablet for time-dependent colon-specific delivery system
title_full_unstemmed A suppository-base-matrix tablet for time-dependent colon-specific delivery system
title_sort suppository-base-matrix tablet for time-dependent colon-specific delivery system
publisher Universidade de São Paulo
series Brazilian Journal of Pharmaceutical Sciences
issn 2175-9790
publishDate 2014-09-01
description Our research has focused on the main design features and release performances of time-dependent colon-specific (TDCS) delivery tablets, which relies on the relative constancy that is observed in the small intestinal transit time of dosage forms. But inflammatory bowel disease(IBD)can affect the transit time, and usually results in watery stool. Compared to the TDCS and wax-matrix TDCS tablet, a promising time-dependent colon-specific delivery system was investigated. In our study, a suppository-base-matrix coated tablet was evaluated. Water soluble suppository-base helps the expansion of tablet, facilitates uniform film dissolution and achives high osmotic pressure. Combining the expansion of carboxymethyl starch sodium (CMS-Na) and the moisture absorption of NaCl, the coated TDCS tablet obtained a burst and targeted drug delivery system. A very good correlation between in vitro drug release and in vivo outcome was observed. This TDCS coated tablet provides a promising strategy to control drug release to the desired lower gastrointestinal region.
topic Doença inflamatória do intestino
Lonicera japonica Thunb./extrato
Supositório/liberação cólon-específica
Fármaco/liberação cólon-específica
Comprimidos/revestidos/liberação cólon específica
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300535&lng=en&tlng=en
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