The role for dickkopf-homolog-1 in the pathogenesis of Crohn's disease-associated fistulae.

The role for dickkopf-homolog-1 in the pathogenesis of Crohn's disease-associated fistulae.

BACKGROUND: One of the most challenging conditions in Crohn's disease (CD) patients is the treatment of perianal fistulae. We have recently shown that epithelial-to-mesenchymal transition (EMT) plays a crucial role during CD-fistulae development. Dickkopf-homolog 1 (DKK-1) is known to play a ke...

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Bibliographic Details
Main Authors: Sandra Michaela Frei, Colette Hemsley, Theresa Pesch, Silvia Lang, Achim Weber, Ekkehard Jehle, Anne Rühl, Michael Fried, Gerhard Rogler, Michael Scharl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3826763?pdf=render

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