Urinary tract infection in renal transplant recipients at a tertiary care center in India

Our objective was to determine incidence, predisposing factors, and microbiological profile of urinary tract infection (UTI) in renal transplant recipients in our center. This was cross-sectional observational study, conducted at the Department of Nephrology, Army Hospital Research and Referral, Del...

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Main Authors: Debabrata Mukherjee, Sourabh Sharma, Ranjith K Nair, Bhaskar Datt, Dhawal Arora, Ananth Rao
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Saudi Journal of Kidney Diseases and Transplantation
Online Access:http://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=2;spage=361;epage=368;aulast=Mukherjee
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spelling doaj-a47864b3a7124b2787ca9b0bd57cff832020-11-25T00:20:38ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422018-01-0129236136810.4103/1319-2442.229294Urinary tract infection in renal transplant recipients at a tertiary care center in IndiaDebabrata MukherjeeSourabh SharmaRanjith K NairBhaskar DattDhawal AroraAnanth RaoOur objective was to determine incidence, predisposing factors, and microbiological profile of urinary tract infection (UTI) in renal transplant recipients in our center. This was cross-sectional observational study, conducted at the Department of Nephrology, Army Hospital Research and Referral, Delhi, India. Two hundred and ten renal transplant recipients were studied over one year. Out of 210 transplant recipients, 69 (32.86%) had UTI. Majority (59/69) had undergone live renal transplantation and 10 cases had received cadaveric grafts. Forty-nine patients had primary infection while 20 patients had recurrences. The mean age of patients with UTI was 38.63 ± 10 years. The incidence of UTI was higher in females (42.25%) than males (28.06%, P = 0.038). Majority of patients in younger age group (age <30 years) were female (58.82%). Males were predominantly affected in higher (>30 years) age group (61.54%). Most common causative agent was Escherichia coli (72.46%). Gram-negative bacilli accounted for 94.20% (65/69) while Gram-positive cocci for 5.8% (4/69) of positive cultures. Multidrug resistance was highest in Klebsiella pneumoniae (100%). Fifteen cases with UTI were detected to have underlying urinary tract abnormalities, most common being urethral stricture (60%). One patient was detected to have broken double J stent in the renal pelvis which led to recurrent E. coli infection. Forty-eight patients (69.57%) developed acute graft dysfunction secondary to UTI. Female sex (P = 0.038), urinary tract abnormality (P <0.01), prolonged Foley's catheterization (P <0.01), prolonged hospitalization after transplantation (P <0.01), new-onset diabetes after transplantation (P <0.01), and coexisting hepatitis C infection (P = 0.012) were statistically significant predisposing factors for UTI in renal transplant recipients.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=2;spage=361;epage=368;aulast=Mukherjee
collection DOAJ
language English
format Article
sources DOAJ
author Debabrata Mukherjee
Sourabh Sharma
Ranjith K Nair
Bhaskar Datt
Dhawal Arora
Ananth Rao
spellingShingle Debabrata Mukherjee
Sourabh Sharma
Ranjith K Nair
Bhaskar Datt
Dhawal Arora
Ananth Rao
Urinary tract infection in renal transplant recipients at a tertiary care center in India
Saudi Journal of Kidney Diseases and Transplantation
author_facet Debabrata Mukherjee
Sourabh Sharma
Ranjith K Nair
Bhaskar Datt
Dhawal Arora
Ananth Rao
author_sort Debabrata Mukherjee
title Urinary tract infection in renal transplant recipients at a tertiary care center in India
title_short Urinary tract infection in renal transplant recipients at a tertiary care center in India
title_full Urinary tract infection in renal transplant recipients at a tertiary care center in India
title_fullStr Urinary tract infection in renal transplant recipients at a tertiary care center in India
title_full_unstemmed Urinary tract infection in renal transplant recipients at a tertiary care center in India
title_sort urinary tract infection in renal transplant recipients at a tertiary care center in india
publisher Wolters Kluwer Medknow Publications
series Saudi Journal of Kidney Diseases and Transplantation
issn 1319-2442
publishDate 2018-01-01
description Our objective was to determine incidence, predisposing factors, and microbiological profile of urinary tract infection (UTI) in renal transplant recipients in our center. This was cross-sectional observational study, conducted at the Department of Nephrology, Army Hospital Research and Referral, Delhi, India. Two hundred and ten renal transplant recipients were studied over one year. Out of 210 transplant recipients, 69 (32.86%) had UTI. Majority (59/69) had undergone live renal transplantation and 10 cases had received cadaveric grafts. Forty-nine patients had primary infection while 20 patients had recurrences. The mean age of patients with UTI was 38.63 ± 10 years. The incidence of UTI was higher in females (42.25%) than males (28.06%, P = 0.038). Majority of patients in younger age group (age <30 years) were female (58.82%). Males were predominantly affected in higher (>30 years) age group (61.54%). Most common causative agent was Escherichia coli (72.46%). Gram-negative bacilli accounted for 94.20% (65/69) while Gram-positive cocci for 5.8% (4/69) of positive cultures. Multidrug resistance was highest in Klebsiella pneumoniae (100%). Fifteen cases with UTI were detected to have underlying urinary tract abnormalities, most common being urethral stricture (60%). One patient was detected to have broken double J stent in the renal pelvis which led to recurrent E. coli infection. Forty-eight patients (69.57%) developed acute graft dysfunction secondary to UTI. Female sex (P = 0.038), urinary tract abnormality (P <0.01), prolonged Foley's catheterization (P <0.01), prolonged hospitalization after transplantation (P <0.01), new-onset diabetes after transplantation (P <0.01), and coexisting hepatitis C infection (P = 0.012) were statistically significant predisposing factors for UTI in renal transplant recipients.
url http://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=2;spage=361;epage=368;aulast=Mukherjee
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