Urinary tract infection in renal transplant recipients at a tertiary care center in India
Our objective was to determine incidence, predisposing factors, and microbiological profile of urinary tract infection (UTI) in renal transplant recipients in our center. This was cross-sectional observational study, conducted at the Department of Nephrology, Army Hospital Research and Referral, Del...
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Wolters Kluwer Medknow Publications
2018-01-01
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doaj-a47864b3a7124b2787ca9b0bd57cff832020-11-25T00:20:38ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422018-01-0129236136810.4103/1319-2442.229294Urinary tract infection in renal transplant recipients at a tertiary care center in IndiaDebabrata MukherjeeSourabh SharmaRanjith K NairBhaskar DattDhawal AroraAnanth RaoOur objective was to determine incidence, predisposing factors, and microbiological profile of urinary tract infection (UTI) in renal transplant recipients in our center. This was cross-sectional observational study, conducted at the Department of Nephrology, Army Hospital Research and Referral, Delhi, India. Two hundred and ten renal transplant recipients were studied over one year. Out of 210 transplant recipients, 69 (32.86%) had UTI. Majority (59/69) had undergone live renal transplantation and 10 cases had received cadaveric grafts. Forty-nine patients had primary infection while 20 patients had recurrences. The mean age of patients with UTI was 38.63 ± 10 years. The incidence of UTI was higher in females (42.25%) than males (28.06%, P = 0.038). Majority of patients in younger age group (age <30 years) were female (58.82%). Males were predominantly affected in higher (>30 years) age group (61.54%). Most common causative agent was Escherichia coli (72.46%). Gram-negative bacilli accounted for 94.20% (65/69) while Gram-positive cocci for 5.8% (4/69) of positive cultures. Multidrug resistance was highest in Klebsiella pneumoniae (100%). Fifteen cases with UTI were detected to have underlying urinary tract abnormalities, most common being urethral stricture (60%). One patient was detected to have broken double J stent in the renal pelvis which led to recurrent E. coli infection. Forty-eight patients (69.57%) developed acute graft dysfunction secondary to UTI. Female sex (P = 0.038), urinary tract abnormality (P <0.01), prolonged Foley's catheterization (P <0.01), prolonged hospitalization after transplantation (P <0.01), new-onset diabetes after transplantation (P <0.01), and coexisting hepatitis C infection (P = 0.012) were statistically significant predisposing factors for UTI in renal transplant recipients.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=2;spage=361;epage=368;aulast=Mukherjee |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Debabrata Mukherjee Sourabh Sharma Ranjith K Nair Bhaskar Datt Dhawal Arora Ananth Rao |
spellingShingle |
Debabrata Mukherjee Sourabh Sharma Ranjith K Nair Bhaskar Datt Dhawal Arora Ananth Rao Urinary tract infection in renal transplant recipients at a tertiary care center in India Saudi Journal of Kidney Diseases and Transplantation |
author_facet |
Debabrata Mukherjee Sourabh Sharma Ranjith K Nair Bhaskar Datt Dhawal Arora Ananth Rao |
author_sort |
Debabrata Mukherjee |
title |
Urinary tract infection in renal transplant recipients at a tertiary care center in India |
title_short |
Urinary tract infection in renal transplant recipients at a tertiary care center in India |
title_full |
Urinary tract infection in renal transplant recipients at a tertiary care center in India |
title_fullStr |
Urinary tract infection in renal transplant recipients at a tertiary care center in India |
title_full_unstemmed |
Urinary tract infection in renal transplant recipients at a tertiary care center in India |
title_sort |
urinary tract infection in renal transplant recipients at a tertiary care center in india |
publisher |
Wolters Kluwer Medknow Publications |
series |
Saudi Journal of Kidney Diseases and Transplantation |
issn |
1319-2442 |
publishDate |
2018-01-01 |
description |
Our objective was to determine incidence, predisposing factors, and microbiological profile of urinary tract infection (UTI) in renal transplant recipients in our center. This was cross-sectional observational study, conducted at the Department of Nephrology, Army Hospital Research and Referral, Delhi, India. Two hundred and ten renal transplant recipients were studied over one year. Out of 210 transplant recipients, 69 (32.86%) had UTI. Majority (59/69) had undergone live renal transplantation and 10 cases had received cadaveric grafts. Forty-nine patients had primary infection while 20 patients had recurrences. The mean age of patients with UTI was 38.63 ± 10 years. The incidence of UTI was higher in females (42.25%) than males (28.06%, P = 0.038). Majority of patients in younger age group (age <30 years) were female (58.82%). Males were predominantly affected in higher (>30 years) age group (61.54%). Most common causative agent was Escherichia coli (72.46%). Gram-negative bacilli accounted for 94.20% (65/69) while Gram-positive cocci for 5.8% (4/69) of positive cultures. Multidrug resistance was highest in Klebsiella pneumoniae (100%). Fifteen cases with UTI were detected to have underlying urinary tract abnormalities, most common being urethral stricture (60%). One patient was detected to have broken double J stent in the renal pelvis which led to recurrent E. coli infection. Forty-eight patients (69.57%) developed acute graft dysfunction secondary to UTI. Female sex (P = 0.038), urinary tract abnormality (P <0.01), prolonged Foley's catheterization (P <0.01), prolonged hospitalization after transplantation (P <0.01), new-onset diabetes after transplantation (P <0.01), and coexisting hepatitis C infection (P = 0.012) were statistically significant predisposing factors for UTI in renal transplant recipients. |
url |
http://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=2;spage=361;epage=368;aulast=Mukherjee |
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