Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922

Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922

The inhibition of heat shock protein 90 (Hsp90) a molecular chaperone for multiple oncogenic client proteins is considered as a promising approach to overcome radioresistance. Since most Hsp90 inhibitors activate HSF-1 that induces the transcription of cytoprotective and tumor-promoting stress prote...

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Bibliographic Details
Main Authors: Annett Kühnel, Daniela Schilling, Stephanie E. Combs, Bernhard Haller, Melissa Schwab, Gabriele Multhoff
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
heat shock factor (hsf-1) knockdown
heat shock proteins 70 and 27
radiosensitization
hsp90 inhibitor nvp-auy922
homologous recombination (hr)
Online Access:https://www.mdpi.com/2073-4409/8/10/1166

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