CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis

CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis

CXCL4 is an inflammatory chemokine signaling through CXCR3 receptor. Here the authors show a CXCR3-independent function of CXCL4: it forms liquid crystals with DNA, potentiating mammalian and bacterial DNA recognition by TLR9, thereby amplifying interferon-a production in systemic sclerosis.

Bibliographic Details
Main Authors:	Roberto Lande, Ernest Y. Lee, Raffaella Palazzo, Barbara Marinari, Immacolata Pietraforte, Giancarlo Santiago Santos, Yves Mattenberger, Francesca Spadaro, Katia Stefanantoni, Nicoletta Iannace, Aleksandra Maria Dufour, Mario Falchi, Manuela Bianco, Elisabetta Botti, Luca Bianchi, Montserrat Alvarez, Valeria Riccieri, Marie-Elise Truchetet, Gerard C.L. Wong, Carlo Chizzolini, Loredana Frasca
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-09683-z

Similar Items

Anti-CXCL4 Antibody Reactivity Is Present in Systemic Sclerosis (SSc) and Correlates with the SSc Type I Interferon Signature
by: Roberto Lande, et al.
Published: (2020-07-01)

New Autoantibody Specificities in Systemic Sclerosis and Very Early Systemic Sclerosis
by: Roberto Lande, et al.
Published: (2021-03-01)

Complementary Effects of Carbamylated and Citrullinated LL37 in Autoimmunity and Inflammation in Systemic Lupus Erythematosus
by: Roberto Lande, et al.
Published: (2021-02-01)

Generation of Monoclonal Antibodies Specific for Native LL37 and Citrullinated LL37 That Discriminate the Two LL37 Forms in the Skin and Circulation of Cutaneous/Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients
by: Roberto Lande, et al.
Published: (2020-05-01)

Overlapping, Additive and Counterregulatory Effects of Type II and I Interferons on Myeloid Dendritic Cell Functions
by: Loredana Frasca, et al.
Published: (2011-01-01)

Anti-LL37 Antibodies Are Present in Psoriatic Arthritis (PsA) Patients: New Biomarkers in PsA
by: Loredana Frasca, et al.
Published: (2018-09-01)

Overproduction of CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 in β-thalassemia major or patients
by: Hamid Najmaddini, et al.
Published: (2014-03-01)

CXCL4 and CXCL4L1 Differentially Affect Monocyte Survival and Dendritic Cell Differentiation and Phagocytosis.
by: Mieke Gouwy, et al.
Published: (2016-01-01)

Functional characterization of CXCL12 and CXCL14 in the ovary
by: Sheng-Wen Wang, et al.
Published: (2014)

Biomarker Significance of Serum CXCL8, CXCL10 and CXCL16 in Breast Tumors of Iraqi Patients
by: Aseel F Khalaf, et al.
Published: (2020-03-01)

Predictive significance of CXCL8, CXCL10 and CXCL16 in juvenile idiopathic and rheumatoid arthritis Iraqi patients
by: Hanan Y. Muhsin, et al.
Published: (2020-04-01)

Effect of JAK Inhibitors on Release of CXCL9, CXCL10 and CXCL11 from Human Airway Epithelial Cells.
by: Peter S Fenwick, et al.
Published: (2015-01-01)

High Levels of CXCL8 and Low Levels of CXCL9 and CXCL10 in Women with Maternal RhD Alloimmunization
by: Juliana Araújo de Carvalho Schettini, et al.
Published: (2017-07-01)

CXCR7 functions as a scavenger for CXCL12 and CXCL11.
by: Ulrike Naumann, et al.
Published: (2010-02-01)

CXCL4 and CXCL10 Predict Risk of Fatal Cerebral Malaria
by: Nana O. Wilson, et al.
Published: (2011-01-01)

CXCL14 antagonizes the CXCL12-CXCR4 signaling axis
by: Hara Takahiko, et al.
Published: (2014-05-01)

The combination of CXCL9, CXCL10 and CXCL11 levels during primary HIV infection predicts HIV disease progression
by: Xiaowan Yin, et al.
Published: (2019-12-01)

Effective Treatments for Bladder Cancer Affecting CXCL9/CXCL10/CXCL11/ CXCR3 Axis: A Review
by: Alireza Nazari, et al.
Published: (2020-03-01)

Expression and migratory analysis of 5 human uveal melanoma cell lines for CXCL12, CXCL8, CXCL1, and HGF
by: Di Cesare Sebastian, et al.
Published: (2007-01-01)

Muscle Damage in Systemic Sclerosis and CXCL10: The Potential Therapeutic Role of PDE5 Inhibition
by: Clarissa Corinaldesi, et al.
Published: (2021-03-01)

Structural and functional correlation of CXCL4 and CXCL4L1 chemokines
by: Chen, Ya-Ping, et al.
Published: (2018)

The Significance of CXCL1 and CXCL8 as Well as Their Specific Receptors in Colorectal Cancer
by: Łukaszewicz-Zając M, et al.
Published: (2020-09-01)

Urinary CXCL9 and CXCL10 Levels and Acute Renal Graft Rejection
by: H Senturk Ciftci, et al.
Published: (2019-05-01)

Evaluation of CXCL9 and CXCL10 as circulating biomarkers of human cardiac allograft rejection
by: Svensson Per-Arne, et al.
Published: (2006-06-01)

Dégradation de CXCL11 et CXCL10 par les lymphocytes T activés
by: Girard, Mélanie
Published: (2017)

Expression of chemokines CXCL4 and CXCL7 in the synovium at an early stage of rheumatoid arthritis
by: Adlard, Nichola Jayne
Published: (2016)

Sildenafil Counteracts the In Vitro Activation of CXCL-9, CXCL-10 and CXCL-11/CXCR3 Axis Induced by Reactive Oxygen Species in Scleroderma Fibroblasts
by: Cristina Antinozzi, et al.
Published: (2021-05-01)

The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11 Are Upregulated Following SARS-CoV-2 Infection in an AKT-Dependent Manner
by: Victoria Callahan, et al.
Published: (2021-06-01)

CXCL8 – The first chemokine
by: Marco eBaggiolini
Published: (2015-06-01)

Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10
by: Schaffer EM, et al.
Published: (2004-08-01)

The contribution of connective tissues to muscle morphogenesis : an unexpected role for CXCL12 and CXCL14 chemokines
by: Nassari, Sonya
Published: (2017)

Sequence characterization and expression pattern analysis of chemokines CXCL13 and CXCL14 in Asian swamp eel
by: Dingda Xu, et al.
Published: (2020-11-01)

A single nucleotide polymorphism of the porcine CXCL8 gene is associated with serum CXCL8 level
by: Shiwei Wang, et al.
Published: (2019-01-01)

Myocardial chemokine expression and intensity of myocarditis in Chagas cardiomyopathy are controlled by polymorphisms in CXCL9 and CXCL10.
by: Luciana Gabriel Nogueira, et al.
Published: (2012-01-01)

Characterization of thymic hyperplasia associated with autoimmune Myasthenia Gravis : role of the chemokines CXCL12 and CXCL13
by: Weiss, Julia
Published: (2011)

In silico study on the mechanism of chemokine ligands CXCL8 and CXCL1 binding to receptor CXCR2
by: Fang-Tzu Chang, et al.
Published: (2015)

Characterization of thymic hyperplasia associated with autoimmune Myasthenia Gravis : role of the chemokines CXCL12 and CXCL13
by: Weiss, Julia Miriam
Published: (2011)

Bu-Shen-Fang-Chuan formula attenuates T-lymphocytes recruitment in the lung of rats with COPD through suppressing CXCL9/CXCL10/CXCL11-CXCR3 axis
by: Qiuping Li, et al.
Published: (2020-03-01)

CXCL8 chemokine in ulcerative colitis
by: Yunfei Zhu, et al.
Published: (2021-06-01)

Regulation of T cell chemotaxis by CXCL4
by: Petersen F, et al.
Published: (2009-02-01)