Cystatin C Plays a Sex-Dependent Detrimental Role in Experimental Autoimmune Encephalomyelitis

Cystatin C Plays a Sex-Dependent Detrimental Role in Experimental Autoimmune Encephalomyelitis

Summary: The cysteine protease inhibitor Cystatin C (CST3) is highly expressed in the brains of multiple sclerosis (MS) patients and C57BL/6J mice with experimental autoimmune encephalomyelitis (EAE; a model of MS), but its roles in the diseases are unknown. Here, we show that CST3 plays a detriment...

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Bibliographic Details
Main Authors: Vahid Hoghooghi, Alexandra L. Palmer, Ariana Frederick, Yulan Jiang, Jessica E. Merkens, Anjali Balakrishnan, Trisha M. Finlay, Anders Grubb, Efrat Levy, Paul Gordon, Frank R. Jirik, Minh Dang Nguyen, Carol Schuurmans, Frank Visser, Shannon E. Dunn, Shalina S. Ousman
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
Cystatin C
CST3
multiple sclerosis
sex effect
experimental allergic encephalomyelitis
antigen-presenting cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312250

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http://www.sciencedirect.com/science/article/pii/S2211124720312250

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