Long-term Effects of Dexamethasone on Reproductive Parameters in Male Mice

• Main Authors: jalogoden Gouyandeh, merdad modaaresi
• Format: Article
• Language: fas
• Published: Yasuj University Of Medical Sciences 2015-02-01
• Series: Armaghane Danesh Bimonthly Journal
• Subjects: Dexamethasone; Reproduction; Testosterone; Male Mice
• Online Access: http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-13&slc_lang=en&sid=1

Background & aim: The adverse effect of chemical drugs such as dexamethasone as anti-inflammatory -steroidal drugs on different body systems and infertility and reproductive efficiency is of concern. The purpose of this study was to evaluate the long-term effects of dexamethasone on the reproductive system in male rats. Methods: In the present experimental study, fifty matured male mice were divided into five groups including control, placebo and three treatment groups. Control group had no injections, placebo group only received normal saline and treatments groups received dexamethasone (0.1, 0.5 and 1 mg/kg) which was injected in peritoneum every other day for a period of twenty days. Their Testosterone was measured by ELISA and testes were dissected for histological examination. The data were analyzed using SPSS 11.5 software. Results: Significant increases were shown in FSH level in all three groups treated with dexamethasone. LH in treatment group of 0.1 mg/kg decreased, but at dose of 1 mg/kg increased significantly.Testosterone levels in a dose of 1 mg/kg significantly increased compared with the control group (p<0.05). However, testis weight, the rate of testicular germ cells, primary spermatocytes, epididymal sperm and fertility significantly increased in all three groups (p<0.05). Conclusion: Dexamethasone had a negative effect on reproduction therefore, the use of this medication at different doses and time periods considers the possible complications beforehand. Keywords: .