Safety and Immunogenicity of a DNA SARS-CoV-2 vaccine (ZyCoV-D): Results of an open-label, non-randomized phase I part of phase I/II clinical study by intradermal route in healthy subjects in India

Safety and Immunogenicity of a DNA SARS-CoV-2 vaccine (ZyCoV-D): Results of an open-label, non-randomized phase I part of phase I/II clinical study by intradermal route in healthy subjects in India

Background: ZyCoV-D is a DNA vaccine candidate, which comprises a plasmid DNA carrying spike-S gene of SARS-CoV-2 virus along with gene coding for signal peptide. The spike(S) region includes the receptor-binding domain (RBD), which binds to the human angiotensin converting Enzyme (ACE)-2 receptor a...

Full description

Bibliographic Details
Main Authors: Taufik Momin, Kevinkumar Kansagra, Hardik Patel, Sunil Sharma, Bhumika Sharma, Jatin Patel, Ravindra Mittal, Jayesh Sanmukhani, Kapil Maithal, Ayan Dey, Harish Chandra, Chozhavel TM Rajanathan, Hari PR Pericherla, Pawan Kumar, Anjali Narkhede, Deven Parmar
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:EClinicalMedicine
Subjects:
DNA
SARS-CoV-2
Vaccine
Neutralizing antibody
COVID-19
Online Access:http://www.sciencedirect.com/science/article/pii/S258953702100300X

Similar Items

Similar Items