H1 but not H2 histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing

H1 but not H2 histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing

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This study investigated the role of H1 and H2 receptors in anxiety and the retrieval of emotional memory using a Trial 1/Trial 2 (T1/T2) protocol in an elevated plus-maze (EPM). Tests were performed on 2 consecutive days, designated T1 and T2. Before T1, the mice received intraperitoneal injections...

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Bibliographic Details
Main Authors: K.R. Serafim, M.S. Kishi, A. Canto-de-Souza, R. Mattioli
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2013-05-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Chlorpheniramine
Zolantidine
Anxiety
Memory
Elevated plus-maze
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000500440

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