Development of a Sensitive Bioassay for the Analysis of IGF-Related Activation of AKT/mTOR Signaling in Biological Matrices

Development of a Sensitive Bioassay for the Analysis of IGF-Related Activation of AKT/mTOR Signaling in Biological Matrices

The bioactivity of the IGF system is not a function of isolated hormone concentrations in a given biological matrix. Instead, the biological activities of IGFs are regulated by IGFBPs, IGFBP proteases, and inhibitors of IGFBP proteases. Therefore, assays based on IGF-related bioactivity may describe...

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Bibliographic Details
Main Authors: Michael Walz, Christine Höflich, Christina Walz, Daniela Ohde, Julia Brenmoehl, Mandy Sawitzky, Andreas Vernunft, Uwe K. Zettl, Susanne Holtze, Thomas B. Hildebrandt, Eckhard Wolf, Andreas Hoeflich
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
IGF
bioactivity
bioassay
mTOR
AKT phosphorylation
serum
Online Access:https://www.mdpi.com/2073-4409/10/3/482

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