Simultaneous Blockade of Histamine H<sub>3</sub> Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-Like Behaviors in BTBR T+ tf/J Mouse Model of Autism

Simultaneous Blockade of Histamine H<sub>3</sub> Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-Like Behaviors in BTBR T+ tf/J Mouse Model of Autism

Autism spectrum disorder (ASD) is a heterogenous neurodevelopmental disorder defined by persistent deficits in social interaction and the presence of patterns of repetitive and restricted behaviors. The central neurotransmitters histamine (HA) and acetylcholine (ACh) play pleiotropic roles in physio...

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Bibliographic Details
Main Authors:	Nermin Eissa, Petrilla Jayaprakash, Holger Stark, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek
Format:	Article
Language:	English
Published:	MDPI AG 2020-08-01
Series:	Biomolecules
Subjects:	autism spectrum disorder BTBR mice histamine histamine H<sub>3</sub> receptor antagonist acetylcholine acetylcholine esterase inhibitor
Online Access:	https://www.mdpi.com/2218-273X/10/9/1251

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