Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells

Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells

While pancreatic islet transplantation achieves insulin independence in type 1 diabetes (T1D) patients, its widespread application is limited by donor tissue scarcity. Pancreatic progenitor cells (PPCs) give rise to all cell types in the pancreas during development. PPCs derived from human pluripote...

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Bibliographic Details
Main Authors: Azuma Kimura, Taro Toyoda, Yohei Nishi, Makoto Nasu, Akira Ohta, Kenji Osafune
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Stem Cell Research
Subjects:
Diabetes
Induced pluripotent stem cell
Pancreatic progenitor cell
Small molecule
Proliferation
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506117301654

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