Impact of Hypoxia on Carbon Ion Therapy in Glioblastoma Cells: Modulation by LET and Hypoxia-Dependent Genes

Impact of Hypoxia on Carbon Ion Therapy in Glioblastoma Cells: Modulation by LET and Hypoxia-Dependent Genes

Tumor hypoxia is known to limit the efficacy of ionizing radiations, a concept called oxygen enhancement ratio (OER). OER depends on physical factors such as pO<sub>2</sub> and linear energy transfer (LET). Biological pathways, such as the hypoxia-inducible transcription factors (HIF), m...

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Bibliographic Details
Main Authors: Samuel Valable, Aurélie N. Gérault, Gaëlle Lambert, Marine M. Leblond, Clément Anfray, Jérôme Toutain, Karim Bordji, Edwige Petit, Myriam Bernaudin, Elodie A. Pérès
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
hypoxia
glioblastoma
heavy ion radiotherapy
carbon ions
erythropoietin
Online Access:https://www.mdpi.com/2072-6694/12/8/2019

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